The human WBSCR22 protein is involved in the biogenesis of the 40S ribosomal subunits in mammalian cells.
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The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesisStructural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomesRibosomal protein S15A augments human osteosarcoma cell proliferation in vitro.The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by Interaction with TRMT112 via Ubiquitin-Proteasome PathwayHuman PDCD2L Is an Export Substrate of CRM1 That Associates with 40S Ribosomal Subunit Precursors.The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer.Trm112, a Protein Activator of Methyltransferases Modifying Actors of the Eukaryotic Translational Apparatus.RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth.WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNAThe G-patch protein NF-κB-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis.WBSCR22 confers oxaliplatin resistance in human colorectal cancer.WBSCR22:TRMT112 methylates guanosine-1639 of 18S rRNA yielding 7-methylguanosine-1639Natural killer cells inhibit oxaliplatin-resistant colorectal cancer by repressing WBSCR22 via upregulating microRNA-146b-5p.
P2860
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The human WBSCR22 protein is involved in the biogenesis of the 40S ribosomal subunits in mammalian cells.
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2013 nî lūn-bûn
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2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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The human WBSCR22 protein is i ...... l subunits in mammalian cells.
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The human WBSCR22 protein is i ...... l subunits in mammalian cells.
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The human WBSCR22 protein is i ...... l subunits in mammalian cells.
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The human WBSCR22 protein is i ...... l subunits in mammalian cells.
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The human WBSCR22 protein is i ...... l subunits in mammalian cells.
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The human WBSCR22 protein is i ...... l subunits in mammalian cells.
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The human WBSCR22 protein is i ...... l subunits in mammalian cells.
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Kadri Õunap
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10.1371/JOURNAL.PONE.0075686
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2013-09-23T00:00:00Z