Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription - sprookjes - yvandenbroek - TriplyDB

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

http://www.wikidata.org/entity/Q35007045

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Mitotic bookmarking by transcription factors Selective inhibition of BET bromodomains Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation Bromodomain Inhibitor Review: Bromodomain and Extra-terminal Family Protein Inhibitors as a Potential New Therapy in Central Nervous System Tumors Epigenetic modulators, modifiers and mediators in cancer aetiology and progression Single cell analysis of transcriptional activation dynamics Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2 Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain Different orientations of low-molecular-weight fragments in the binding pocket of a BRD4 bromodomain Resetting a functional G1 nucleus after mitosis The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes The mechanisms behind the therapeutic activity of BET bromodomain inhibition BET bromodomain inhibition as a therapeutic strategy to target c-Myc BET domain co-regulators in obesity, inflammation and cancer Two faces of brd4: mitotic bookmark and transcriptional lynchpin Activation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stress Registered report: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukemia Registered report: BET bromodomain inhibition as a therapeutic strategy to target c-Myc Identification of novel potent human testis-specific and bromodomain-containing protein (BRDT) inhibitors using crystal structure-based virtual screening Targeting MYC dependence in cancer by inhibiting BET bromodomains Drug Discovery Targeting Bromodomain-Containing Protein 4.The role of foxi family transcription factors in the development of the ear and jaw.Disordered epigenetic regulation in MLL-related leukemia.The C-terminal domain of Brd2 is important for chromatin interaction and regulation of transcription and alternative splicing.Characterization of BRD4 during mammalian postmeiotic sperm development.A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition.Papillomavirus genomes associate with BRD4 to replicate at fragile sites in the host genome.Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628 Epigenetic characteristics of the mitotic chromosome in 1D and 3D.Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory Bookmarking promoters in mitotic chromatin: poly(ADP-ribose)polymerase-1 as an epigenetic mark Inducible STAT3 NH2 terminal mono-ubiquitination promotes BRD4 complex formation to regulate apoptosis BET proteins are a key component of immunoglobulin gene expression.Mechanism and factors that control HIV-1 transcription and latency activation The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo.Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4.

P2860

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P2860

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

http://www.wikidata.org/entity/Q35007045

description

2009 nî lūn-bûn

@nan

2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

@ast

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

@en

type

label

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

@ast

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

@en

prefLabel

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

@ast

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

@en

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MBC.E09-05-0380

P1433

Molecular Biology of the Cell

P1476

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

@en

P2093

Akira Nishiyama

http://www.w3.org/2001/XMLSchema#string

Anup Dey

http://www.w3.org/2001/XMLSchema#string

James McNally

http://www.w3.org/2001/XMLSchema#string

Keiko Ozato

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P2860

A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition

Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression

Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin.

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

Histone modifications defining active genes persist after transcriptional and mitotic inactivation

The TBP-PP2A mitotic complex bookmarks genes by preventing condensin action

Combinatorial patterns of histone acetylations and methylations in the human genome

Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription

Selective recognition of acetylated histones by bromodomain proteins visualized in living cells

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4899-4909

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scholarly article

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10.1091/MBC.E09-05-0380

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23

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20

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Tatiana Karpova

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2009-10-07T00:00:00Z

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26879103

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19812244

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2785733

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