Mechanisms underlying abnormal trafficking and expansion of malignant progenitors in CML: BCR/ABL-induced defects in integrin function in CML.
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Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathwayBCR/ABL-mediated downregulation of genes implicated in cell adhesion and motility leads to impaired migration toward CCR7 ligands CCL19 and CCL21 in primary BCR/ABL-positive cellsC3G forms complexes with Bcr-Abl and p38α MAPK at the focal adhesions in chronic myeloid leukemia cells: implication in the regulation of leukemic cell adhesion.Using Bcr-Abl to examine mechanisms by which abl kinase regulates morphogenesis in Drosophila.BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility.Changes in cell adhesivity and cytoskeleton-related proteins during imatinib-induced apoptosis of leukemic JURL-MK1 cells.Novel approach for coexpression analysis of E2F1-3 and MYC target genes in chronic myelogenous leukemia.Extensive gene-specific translational reprogramming in a model of B cell differentiation and Abl-dependent transformationRight on target: eradicating leukemic stem cells.Gene expression profile of circulating CD34(+) cells and granulocytes in chronic myeloid leukemiaAbi1 gene silencing by short hairpin RNA impairs Bcr-Abl-induced cell adhesion and migration in vitro and leukemogenesis in vivo.Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib.Coexpression Pattern Analysis of NPM1-Associated Genes in Chronic Myelogenous Leukemia.FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1.Co-expression Pattern Analysis of miR-17-92 Target Genes in Chronic Myelogenous Leukemia.c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migrationLack of alpha4 integrin expression in stem cells restricts competitive function and self-renewal activity.Gene network exploration of crosstalk between apoptosis and autophagy in chronic myelogenous leukemia.Real-time monitoring of hematopoietic cell interaction with fibronectin fragment: the effect of histone deacetylase inhibitors.Mathematical modelling of miRNA mediated BCR.ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies.Electrospun nanofibers as a bioadhesive platform for capturing adherent leukemia cells.Monocyte-derived dendritic cells from chronic myeloid leukaemia have abnormal maturation and cytoskeletal function that is associated with defective localisation and signalling by normal ABL1 protein.Pro-survival role of protein kinase C epsilon in Philadelphia chromosome positive acute leukemia.
P2860
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P2860
Mechanisms underlying abnormal trafficking and expansion of malignant progenitors in CML: BCR/ABL-induced defects in integrin function in CML.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Mechanisms underlying abnormal ...... s in integrin function in CML.
@ast
Mechanisms underlying abnormal ...... s in integrin function in CML.
@en
type
label
Mechanisms underlying abnormal ...... s in integrin function in CML.
@ast
Mechanisms underlying abnormal ...... s in integrin function in CML.
@en
prefLabel
Mechanisms underlying abnormal ...... s in integrin function in CML.
@ast
Mechanisms underlying abnormal ...... s in integrin function in CML.
@en
P2860
P356
P1433
P1476
Mechanisms underlying abnormal ...... s in integrin function in CML.
@en
P2093
Stephanie Salesse
P2860
P2888
P304
P356
10.1038/SJ.ONC.1206088
P407
P577
2002-12-01T00:00:00Z
P5875
P6179
1034440897