Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers - sprookjes - yvandenbroek - TriplyDB

Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

http://www.wikidata.org/entity/Q35025021

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Epigenetic Alterations in Alzheimer's Disease Profiling technologies for the identification and characterization of small-molecule histone deacetylase inhibitors Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration Maternal Exposure of Rats to Isoflurane during Late Pregnancy Impairs Spatial Learning and Memory in the Offspring by Up-Regulating the Expression of Histone Deacetylase 2.Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue.An Evolutionarily Conserved SoxB-Hdac2 Crosstalk Regulates Neurogenesis in a Cnidarian.Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.Emerging approaches for histone deacetylase inhibitor drug discovery.Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia.Epigenetic Treatment of Neuropsychiatric Disorders: Autism and Schizophrenia.CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells Combinatorial In Silico Strategy towards Identifying Potential Hotspots during Inhibition of Structurally Identical HDAC1 and HDAC2 Enzymes for Effective Chemotherapy against Neurological Disorders.Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability.Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity.Propofol exposure during early gestation impairs learning and memory in rat offspring by inhibiting the acetylation of histone.Synaptic Dysfunction in Alzheimer's Disease: Aβ, Tau, and Epigenetic Alterations.GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia.

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Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

http://www.wikidata.org/entity/Q35025021

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2015 թվականի հունվարին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

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Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

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Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

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Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

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Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

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Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

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Chemical Science

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Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers

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B C Lemercier

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D M Fass

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E B Holson

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E Scolnick

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F F Wagner

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J P Gale

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K M Hennig

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M C Lewis

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M P Moyer

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P2860

HDAC2 negatively regulates memory formation and synaptic plasticity.

An epigenetic blockade of cognitive functions in the neurodegenerating brain

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Small molecule inhibitors of zinc-dependent histone deacetylases

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease

Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis

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804-815

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10.1039/C4SC02130D

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1

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6

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Stephen J Haggarty

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2015-01-01T00:00:00Z

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