Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. - sprookjes - yvandenbroek - TriplyDB

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

http://www.wikidata.org/entity/Q35125938

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Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis Hepcidin: A Promising Therapeutic Target for Iron Disorders: A Systematic Review Hepcidin and iron homeostasis Mechanisms of mammalian iron homeostasis The role of TMPRSS6/matriptase-2 in iron regulation and anemia Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches Bmp6 expression in murine liver non parenchymal cells: a mechanism to control their high iron exporter activity and protect hepatocytes from iron overload?Effect of Erythropoietin, Iron Deficiency and Iron Overload on Liver Matriptase-2 (TMPRSS6) Protein Content in Mice and Rats Iron regulation by hepcidin Targeting iron metabolism in drug discovery and delivery MicroRNA-130a is up-regulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription.Inflammation regulates TMPRSS6 expression via STAT5.Low intracellular iron increases the stability of matriptase-2.Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia.Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage.Progesterone receptor membrane component-1 regulates hepcidin biosynthesis A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum.Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.Exogenous heparin binds and inhibits bone morphogenetic protein 6 biological activity.A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis.Iron refractory iron deficiency anemia Identification and characterization of a novel murine allele of Tmprss6.A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats.Out of balance--systemic iron homeostasis in iron-related disorders The liver: conductor of systemic iron balance.Bone grafts, bone substitutes and orthobiologics: the bridge between basic science and clinical advancements in fracture healing.Repulsive guidance molecules (RGMs) and neogenin in bone morphogenetic protein (BMP) signaling.The regulation of iron transport.Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis.A Red Carpet for Iron Metabolism.Systemic iron homeostasis and erythropoiesis.The liver in regulation of iron homeostasis.The erythroid function of transferrin receptor 2 revealed by Tmprss6 inactivation in different models of transferrin receptor 2 knockout mice.Inactive matriptase-2 mutants found in IRIDA patients still repress hepcidin in a transfection assay despite having lost their serine protease activity.Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing.Liver iron modulates hepcidin expression during chronically elevated erythropoiesis in mice.Monitoring of residual disease by next-generation deep-sequencing of RUNX1 mutations can identify acute myeloid leukemia patients with resistant disease.Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway.

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Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

http://www.wikidata.org/entity/Q35125938

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

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Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

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type

label

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

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Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

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Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

@ast

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

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Regulation of TMPRSS6 by BMP6 and iron in human cells and mice.

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Charles C Hong

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Chia Chi Sun

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Delphine Meynard

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Herbert Y Lin

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Jodie L Babitt

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Lovorka Grgurevic

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Marit Stirnberg

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Michael Gütschow

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Shanzhuo Chen

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Slobodan Vukicevic

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P2860

Systemically administered bone morphogenetic protein-6 restores bone in aged ovariectomized rats by increasing bone formation and suppressing bone resorption

Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

A mouse model of juvenile hemochromatosis.

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

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Carlos López Otín

Elena Corradini

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51174814

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