Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
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Myocilin stimulates osteogenic differentiation of mesenchymal stem cells through mitogen-activated protein kinase signalingExperimentally Induced Mammalian Models of GlaucomaOverexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma.Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma.Rodent models of glaucoma.Expression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: implication for glaucoma pathogenesisDown-regulation of GRP78 in human glaucomatous trabecular meshwork cells.Olfactomedin domain-containing proteins: possible mechanisms of action and functions in normal development and pathology.Aqueous humor rapidly stimulates myocilin secretion from human trabecular meshwork cells.A role for myocilin in receptor-mediated endocytosis.Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma.Molecular chaperone function for myocilinPerfusion-cultured bovine anterior segments as an ex vivo model for studying glucocorticoid-induced ocular hypertension and glaucoma.Mutated myocilin and heterozygous Sod2 deficiency act synergistically in a mouse model of open-angle glaucoma.Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma.Prospectives for gene therapy of retinal degenerationsLow prevalence of myocilin mutations in an African American population with primary open-angle glaucomaUsing genetic mouse models to gain insight into glaucoma: Past results and future possibilities.Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.Heterozygous expression of myocilin glaucoma mutants increases secretion of the mutant forms and reduces extracellular processed myocilin.Regulation of myocilin-associated exosome release from human trabecular meshwork cellsGlaucoma-associated myocilin: a better understanding but much more to learn.Glaucoma genetics.Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular MeshworkRole of MYOC and OPTN sequence variations in Spanish patients with primary open-angle glaucomaA Novel Luciferase Assay For Sensitively Monitoring Myocilin Variants in Cell Culture.Primary open-angle glaucoma genes.Molecular genetics in glaucoma.Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine.Major review: Molecular genetics of primary open-angle glaucoma.Toward a Genetic Understanding of Glaucoma-Breakthroughs and Challenges from Studies of Exfoliation Glaucoma.Myocilin Regulates Metalloprotease 2 Activity Through Interaction With TIMP3.Dexamethasone-Induced Ocular Hypertension in Mice: Effects of Myocilin and Route of Administration.
P2860
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P2860
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
@ast
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
@en
type
label
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
@ast
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
@en
prefLabel
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
@ast
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
@en
P2093
P2860
P356
P1476
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.
@en
P2093
Douglas B Gould
Lawriston A Wilson
Mark Reedy
Randy L Johnson
Richard S Smith
Simon W M John
P2860
P304
P356
10.1128/MCB.01127-06
P407
P577
2006-09-05T00:00:00Z