Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia. - sprookjes - yvandenbroek - TriplyDB

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q35213566

about

ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies Genomic profiling of B-progenitor acute lymphoblastic leukemia Current concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia Murine models of acute leukemia: important tools in current pediatric leukemia research.Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia.Regulation of the interferon regulatory factor-8 (IRF-8) tumor suppressor gene by the signal transducer and activator of transcription 5 (STAT5) transcription factor in chronic myeloid leukemia A capture-sequencing strategy identifies IRF8, EBF1, and APRIL as novel IGH fusion partners in B-cell lymphoma.LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients.PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia.PAX Genes in Cancer; Friends or Foes?Rationale for targeting the pre-B-cell receptor signaling pathway in acute lymphoblastic leukemia.Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/-) leukemia.Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors.Lentiviral vector induced insertional haploinsufficiency of Ebf1 causes murine leukemia.Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.Context-specific roles for paracrine IL-6 in lymphomagenesis.Molecular genetics of B-precursor acute lymphoblastic leukemia Mouse Lymphoblastic Leukemias Induced by Aberrant Prdm14 Expression Demonstrate Widespread Copy Number Alterations Also Found in Human ALL.B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia Synergism of FAK and tyrosine kinase inhibition in Ph+ B-ALL.DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia Genomic characterization of childhood acute lymphoblastic leukemia.Acute lymphoblastic leukemia and developmental biology: a crucial interrelationship The role of STAT5 in lymphocyte development and transformation B-lineage transcription factors and cooperating gene lesions required for leukemia development.The role of Pax5 in leukemia: diagnosis and prognosis significance.Genetically engineered mouse models of human B-cell precursor leukemias.Mechanisms of pre-B-cell receptor checkpoint control and its oncogenic subversion in acute lymphoblastic leukemia.Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia.STAT5 activation in B-cell acute lymphoblastic leukemia: damned if you do, damned if you don't.Molecular role of the PAX5-ETV6 oncoprotein in promoting B-cell acute lymphoblastic leukemia.PhenomeExpress: a refined network analysis of expression datasets by inclusion of known disease phenotypes.Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia Spontaneous loss of B lineage transcription factors leads to pre-B leukemia in Ebf1+/-Bcl-xLTg mice Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.Chromosomal Aberrations in ETV6/RUNX1-positive Childhood Acute Lymphoblastic Leukemia using 244K Oligonucleotide Array Comparative Genomic Hybridization Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia.

P2860

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P2860

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q35213566

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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name

Ebf1 or Pax5 haploinsufficienc ...... acute lymphoblastic leukemia.

@ast

Ebf1 or Pax5 haploinsufficienc ...... acute lymphoblastic leukemia.

@en

type

label

Ebf1 or Pax5 haploinsufficienc ...... acute lymphoblastic leukemia.

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Ebf1 or Pax5 haploinsufficienc ...... acute lymphoblastic leukemia.

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prefLabel

Ebf1 or Pax5 haploinsufficienc ...... acute lymphoblastic leukemia.

@ast

Ebf1 or Pax5 haploinsufficienc ...... acute lymphoblastic leukemia.

@en

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P2860

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P1433

Journal of Experimental Medicine

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Ebf1 or Pax5 haploinsufficienc ...... acute lymphoblastic leukemia.

@en

P2093

Deborah A Thomas

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E Shannon Neeley

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Emily C Baechler

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Lynn M Heltemes-Harris

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Mark J L Willette

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Nianxiang Zhang

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Steven M Kornblau

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Thearith Koeuth

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Yi Hua Qiu

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P2860

Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73

TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)

Molecular cloning of complex chromosomal translocation t(8;14;12)(q24.1;q32.3;q24.1) in a Burkitt lymphoma cell line defines a new gene (BCL7A) with homology to caldesmon

Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway

BTG1, a member of a new family of antiproliferative genes

The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13

A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5

P304

1135-1149

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scholarly article

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10.1084/JEM.20101947

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P433

6

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208

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Michael A Farrar

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2011-05-23T00:00:00Z

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51159966

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21606506

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P921

haploinsufficiency

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3173246

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