Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.
about
Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1-Mad2.Centrosome - a promising anti-cancer targetThe Toxoplasma gondii centrosome is the platform for internal daughter budding as revealed by a Nek1 kinase mutantThe 68-kDa telomeric repeat binding factor 1 (TRF1)-associated protein (TAP68) interacts with and recruits TRF1 to the spindle pole during mitosis"Stop Ne(c)king around": How interactomics contributes to functionally characterize Nek family kinasesEffect of NDC80 in human hepatocellular carcinomaThe Set1/COMPASS histone H3 methyltransferase helps regulate mitosis with the CDK1 and NIMA mitotic kinases in Aspergillus nidulansNek2 is a novel regulator of B cell development and immunological response.Role of NEK2A in human cancer and its therapeutic potentials.Structural organization of the kinetochore-microtubule interface.Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosisASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments.The KMN protein network--chief conductors of the kinetochore orchestraNek2-targeted ASO or siRNA pretreatment enhances anticancer drug sensitivity in triple‑negative breast cancer cells.Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.Targeting NEK2 as a promising therapeutic approach for cancer treatment.Histone deacetylase inhibitors modulate miRNA and mRNA expression, block metaphase, and induce apoptosis in inflammatory breast cancer cellsEmerging roles of sumoylation in the regulation of actin, microtubules, intermediate filaments, and septinsComplementary interhelical interactions between three buried Glu-Lys pairs within three heptad repeats are essential for Hec1-Nuf2 heterodimerization and mitotic progression.Cancerous inhibitor of protein phosphatase 2A (CIP2A) protein is involved in centrosome separation through the regulation of NIMA (never in mitosis gene A)-related kinase 2 (NEK2) protein activity.Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1.Mitotic perturbations induced by Nek2 overexpression require interaction with TRF1 in breast cancer cells.Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity.Inhibition of Hec1 expression enhances the sensitivity of human ovarian cancer cells to paclitaxel.Regulatory mechanisms of kinetochore-microtubule interaction in mitosis.Cell cycle regulation by the NEK family of protein kinases.Mitosis as an anti-cancer drug target.Signalling dynamics in the spindle checkpoint response.Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2.Inhibition of Hec1 as a novel approach for treatment of primary liver cancer.Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism.TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCCMeta-analysis of microarray datasets identify several chromosome segregation-related cancer/testis genes potentially contributing to anaplastic thyroid carcinoma
P2860
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P2860
Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Phosphorylation of the Ndc80 c ...... e spindle assembly checkpoint.
@ast
Phosphorylation of the Ndc80 c ...... e spindle assembly checkpoint.
@en
type
label
Phosphorylation of the Ndc80 c ...... e spindle assembly checkpoint.
@ast
Phosphorylation of the Ndc80 c ...... e spindle assembly checkpoint.
@en
prefLabel
Phosphorylation of the Ndc80 c ...... e spindle assembly checkpoint.
@ast
Phosphorylation of the Ndc80 c ...... e spindle assembly checkpoint.
@en
P2093
P2860
P356
P1476
Phosphorylation of the Ndc80 c ...... he spindle assembly checkpoint
@en
P2093
P2860
P304
P356
10.1091/MBC.E11-01-0012
P50
P577
2011-08-10T00:00:00Z