Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism
about
Botulinum neurotoxin type-A enters a non-recycling pool of synaptic vesicles.Actin- and dynamin-dependent maturation of bulk endocytosis restores neurotransmission following synaptic depletionInhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell deathPharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophagesBotulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neuronsBotulinum Toxin as a Pain Killer: Players and Actions in AntinociceptionPhenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis.Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis.Conformational biosensors reveal GPCR signalling from endosomes.Single Molecule Imaging Deciphers the Relation between Mobility and Signaling of a Prototypical G Protein-coupled Receptor in Living Cells.Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkBDrebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis.Preferential entry of botulinum neurotoxin A Hc domain through intestinal crypt cells and targeting to cholinergic neurons of the mouse intestineDynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers.The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening.Dynamin-2 regulates fusion pore expansion and quantal release through a mechanism that involves actin dynamics in neuroendocrine chromaffin cells1,8-Naphthalimide derivatives: new leads against dynamin I GTPase activity.Membrane protrusion powers clathrin-independent endocytosis of interleukin-2 receptorInflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system.Botulinum Neurotoxins Can Enter Cultured Neurons Independent of Synaptic Vesicle RecyclingThe Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pHPhosphatidylserine dynamics in cellular membranes.Botulinum neurotoxin type A inhibits synaptic vesicle 2 expression in breast cancer cell linesDynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa.A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins.Rapid synaptic vesicle endocytosis in cone photoreceptors of salamander retinaControl of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type aA nibbling mechanism for clathrin-mediated retrieval of secretory granule membrane after exocytosisDynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitorsSubdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles.Spatially restricted G protein-coupled receptor activity via divergent endocytic compartments.Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor signaling.Vesicle dynamics: how synaptic proteins regulate different modes of neurotransmission.Na+ /H+ exchange via the Drosophila vesicular glutamate transporter mediates activity-induced acid efflux from presynaptic terminals.Dynamin function is important for chemokine receptor-induced cell migration.Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cellsChallenges in searching for therapeutics against Botulinum Neurotoxins.Dynamin inhibitors impair endocytosis and mitogenic signaling of PDGF.Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology.
P2860
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P2860
Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Dynamin inhibition blocks botu ...... in neurons and delays botulism
@ast
Dynamin inhibition blocks botu ...... in neurons and delays botulism
@en
type
label
Dynamin inhibition blocks botu ...... in neurons and delays botulism
@ast
Dynamin inhibition blocks botu ...... in neurons and delays botulism
@en
prefLabel
Dynamin inhibition blocks botu ...... in neurons and delays botulism
@ast
Dynamin inhibition blocks botu ...... in neurons and delays botulism
@en
P2093
P2860
P50
P356
P1476
Dynamin inhibition blocks botu ...... in neurons and delays botulism
@en
P2093
Anna Mariana
Callista B Harper
Gordana Hadzic
Michel R Popoff
Nickolas A Lavidis
Shari J Daniels
Tam H Nguyen
P2860
P304
35966-35976
P356
10.1074/JBC.M111.283879
P407
P577
2011-08-05T00:00:00Z