Synaptic microcircuit dysfunction in genetic models of neurodevelopmental disorders: focus on Mecp2 and Met. - sprookjes - yvandenbroek - TriplyDB

Synaptic microcircuit dysfunction in genetic models of neurodevelopmental disorders: focus on Mecp2 and Met.

Synaptic microcircuit dysfunction in genetic models of neurodevelopmental disorders: focus on Mecp2 and Met.

http://www.wikidata.org/entity/Q35417476

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Rett Syndrome: Crossing the Threshold to Clinical Translation Therapeutic approaches for shankopathies Wnt signaling networks in autism spectrum disorder and intellectual disability Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders Sleep and circadian dysfunction in neurodegenerative disorders: insights from a mouse model of Huntington's disease Circadian dysfunction may be a key component of the non-motor symptoms of Parkinson's disease: insights from a transgenic mouse model Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures Mechanisms of Functional Hypoconnectivity in the Medial Prefrontal Cortex of Mecp2 Null Mice.A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome.Brain activity mapping in Mecp2 mutant mice reveals functional deficits in forebrain circuits, including key nodes in the default mode network, that are reversed with ketamine treatment.Preclinical research in Rett syndrome: setting the foundation for translational success.The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS.Cell-autonomous alterations in dendritic arbor morphology and connectivity induced by overexpression of MeCP2 in Xenopus central neurons in vivo Alterations in the cholinergic system of brain stem neurons in a mouse model of Rett syndrome Astrocyte-specific regulation of hMeCP2 expression in Drosophila.Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice Modulation of the genome and epigenome of individuals susceptible to autism by environmental risk factors PTP1B inhibition suggests a therapeutic strategy for Rett syndrome Emergence of functional subnetworks in layer 2/3 cortex induced by sequential spikes in vivo.Excitatory synapses are stronger in the hippocampus of Rett syndrome mice due to altered synaptic trafficking of AMPA-type glutamate receptors.MeCP2 regulates ethanol sensitivity and intake.Loss of function of KIAA2022 causes mild to severe intellectual disability with an autism spectrum disorder and impairs neurite outgrowth.NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2.Does microglial dysfunction play a role in autism and Rett syndrome?Breathing challenges in Rett syndrome: lessons learned from humans and animal models.Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome.Lovastatin fails to improve motor performance and survival in methyl-CpG-binding protein2-null mice What does the developing brain tell us about neural diseases?The role of oxidative stress in Rett syndrome: an overview.Corticostriatal connectivity and its role in disease LSD1 Neurospecific Alternative Splicing Controls Neuronal Excitability in Mouse Models of Epilepsy.The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and δ-Catenin Signaling.Neurobiology meets genomic science: the promise of human-induced pluripotent stem cells.Functional conservation of MBD proteins: MeCP2 and Drosophila MBD proteins alter sleep.Activation of the Medial Prefrontal Cortex Reverses Cognitive and Respiratory Symptoms in a Mouse Model of Rett Syndrome mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice.Developmental abnormalities of cortical interneurons precede symptoms onset in a mouse model of Rett syndrome.Differential regulation of axonal growth and neuromuscular junction assembly by HGF/c-Met signaling.Circadian Dysfunction in Parkinson's Disease

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Synaptic microcircuit dysfunction in genetic models of neurodevelopmental disorders: focus on Mecp2 and Met.

http://www.wikidata.org/entity/Q35417476

description

2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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Synaptic microcircuit dysfunct ...... rders: focus on Mecp2 and Met.

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Synaptic microcircuit dysfunct ...... rders: focus on Mecp2 and Met.

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J.CONB.2011.06.006

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Current Opinion in Neurobiology

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Synaptic microcircuit dysfunct ...... rders: focus on Mecp2 and Met.

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David M Katz

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Gordon M G Shepherd

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P2860

Advances in autism genetics: on the threshold of a new neurobiology

Neuroligins and neurexins link synaptic function to cognitive disease

The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders

The teratology of autism

Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3.

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome

Pathophysiology of locus ceruleus neurons in a mouse model of Rett syndrome

The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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827-833

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scholarly article

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10.1016/J.CONB.2011.06.006

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6

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21

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2011-07-04T00:00:00Z

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51471643

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21733672

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neurodevelopmental disorders

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3199024

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