Studying clonal dynamics in response to cancer therapy using high-complexity barcoding. - sprookjes - yvandenbroek - TriplyDB

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

http://www.wikidata.org/entity/Q35596310

about

The steady progress of targeted therapies, promising advances for lung cancer Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine The influence of subclonal resistance mutations on targeted cancer therapy A high-content image-based method for quantitatively studying context-dependent cell population dynamics Molecular Characterization of Epithelial Ovarian Cancer: Implications for Diagnosis and Treatment Molecular pathology of cancer: how to communicate with disease Patient-derived tumour xenografts for breast cancer drug discovery Model Based Analysis of Clonal Developments Allows for Early Detection of Monoclonal Conversion and Leukemia Modeling Tumor Clonal Evolution for Drug Combinations Design Glucose metabolism-targeted therapy and withaferin A are effective for epidermal growth factor receptor tyrosine kinase inhibitor-induced drug-tolerant persisters.Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion.TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity.Big-data-based edge biomarkers: study on dynamical drug sensitivity and resistance in individuals.The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes.Site-specific recombinatorics: in situ cellular barcoding with the Cre Lox system An in vivo multiplexed small-molecule screening platform.Limitations and challenges of genetic barcode quantification.SIApopr: A computational method to simulate evolutionary branching trees for analysis of tumor clonal evolution.Improving Cancer Treatment via Mathematical Modeling: Surmounting the Challenges Is Worth the Effort Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms.Developmental Insights into Breast Cancer Intratumoral Heterogeneity.Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells.When (distant) relatives stay too long: implications for cancer medicine.Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition.A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine.De novo intrachromosomal gene conversion from OPN1MW to OPN1LW in the male germline results in Blue Cone Monochromacy Reciprocal positive selection for weakness - preventing olaparib resistance by inhibiting BRCA2.Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations.Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution.Cancer cells exhibit clonal diversity in phenotypic plasticity.The impact of structural biology in medicine illustrated with four case studies.JNK Pathway Activation Modulates Acquired Resistance to EGFR/HER2-Targeted Therapies.Intra-tumour heterogeneity - going beyond genetics.Profiling lung adenocarcinoma by liquid biopsy: can one size fit all?Targeting metastasis.Genetic analysis of uterine aspirates improves the diagnostic value and captures the intra-tumor heterogeneity of endometrial cancers.Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma.Proteogenomic studies on cancer drug resistance: towards biomarker discovery and target identification.Clonal cooperativity in heterogenous cancers.Hypermutation signature reveals a slippage and realignment model of translesion synthesis by Rev3 polymerase in cisplatin-treated yeast.

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Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

http://www.wikidata.org/entity/Q35596310

description

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2015年论文

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2015年论文

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2015年论文

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name

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

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Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

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type

label

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

@ast

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

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prefLabel

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

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Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.

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Nature Medicine

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Studying clonal dynamics in response to cancer therapy using high-complexity barcoding

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P2093

Alina Raza

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Angad P Singh

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Daniel Rakiec

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David A Ruddy

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Frank Stegmeier

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Franziska Michor

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Iris Kao

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Joshua M Korn

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Justina X Caushi

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Marissa Balak

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P2860

Evolutionary dynamics of cancer in response to targeted combination therapy

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

TopHat: discovering splice junctions with RNA-Seq

Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.

Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

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440-448

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scholarly article

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10.1038/NM.3841

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5

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21

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Hyo-eun C Bhang

Elizabeth Ackley

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2015-04-13T00:00:00Z

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274643464

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25849130

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