PPARalpha agonist-induced rodent tumors: modes of action and human relevance.
about
Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and humanOccupational exposure to diisononyl phthalate (DiNP) in polyvinyl chloride processing operationsEpidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA)Structure-activity-dependent regulation of cell communication by perfluorinated fatty acids using in vivo and in vitro model systemsHistorical comparison of perfluorooctanesulfonate, perfluorooctanoate, and other fluorochemicals in human bloodPhthalate exposure and early thelarchePhenobarbital induces alterations in the proteome of hepatocytes and mesenchymal cells of rat liversPrediction of the Carcinogenic Potential of Human Pharmaceuticals Using Repeated Dose Toxicity Data and Their Pharmacological Properties.A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and immunological health conditions in humansDisruptive environmental chemicals and cellular mechanisms that confer resistance to cell deathThe potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signallingMolecular targets of dietary polyphenols with anti-inflammatory propertiesMechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalateHuman health effects of tetrachloroethylene: key findings and scientific issuesThe use of biomonitoring data in exposure and human health risk assessmentsThe effects of di(2-ethylhexyl)phthalate on rat liver in relation to selenium statusUsing nuclear receptor activity to stratify hepatocarcinogensComparative gene expression profiles induced by PPARγ and PPARα/γ agonists in human hepatocytesRegulation of peroxisome proliferator-activated receptor-alpha by MDM2.Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats.Predictive model of rat reproductive toxicity from ToxCast high throughput screening.Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study.Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonistsComparative proteomic analysis on human L-02 liver cells treated with varying concentrations of trichloroethylene.Compound cytotoxicity profiling using quantitative high-throughput screening.Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha).The mouse carcinogenicity study is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides.A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants.Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activatorThe Key Events Dose-Response Framework: a cross-disciplinary mode-of-action based approach to examining dose-response and thresholds.In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast projectA single amino acid change humanizes long-chain fatty acid binding and activation of mouse peroxisome proliferator-activated receptor α.Use of transcriptomics in understanding mechanisms of drug-induced toxicityPeroxisome proliferator-activated receptors alpha, Beta, and gamma mRNA and protein expression in human fetal tissues.Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activityThe Role of PPARα Activation in Liver and Muscle.Influence of fenofibrate treatment on triacylglycerides, diacylglycerides and fatty acids in fructose fed ratsNuclear receptors and pathogenesis of pancreatic cancer.Developmental effects of perfluorononanoic Acid in the mouse are dependent on peroxisome proliferator-activated receptor-alpha.Gene Expression Profiling in Wild-Type and PPARα-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARα-Independent Effects
P2860
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P2860
PPARalpha agonist-induced rodent tumors: modes of action and human relevance.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
PPARalpha agonist-induced rodent tumors: modes of action and human relevance.
@ast
PPARalpha agonist-induced rodent tumors: modes of action and human relevance.
@en
type
label
PPARalpha agonist-induced rodent tumors: modes of action and human relevance.
@ast
PPARalpha agonist-induced rodent tumors: modes of action and human relevance.
@en
prefLabel
PPARalpha agonist-induced rodent tumors: modes of action and human relevance.
@ast
PPARalpha agonist-induced rodent tumors: modes of action and human relevance.
@en
P2093
P2860
P356
P1476
PPARalpha agonist-induced rodent tumors: modes of action and human relevance.
@en
P2093
David Y Lai
J Chris Corton
James E Klaunig
Jeffrey M Peters
John G DeLuca
Jon C Cook
Karl P Baetcke
Michael A Babich
Penelope A Fenner-Crisp
Raymond M David
P2860
P304
P356
10.1080/713608372
P407
P577
2003-01-01T00:00:00Z