Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8.1 and the production of infectious virus.
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Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replicationIdentification of direct transcriptional targets of the Kaposi's sarcoma-associated herpesvirus Rta lytic switch protein by conditional nuclear localizationKaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways.Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression.Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57.Herpesvirus BACs: past, present, and future.KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome.Attenuation of the suppressive activity of cellular splicing factor SRSF3 by Kaposi sarcoma-associated herpesvirus ORF57 protein is required for RNA splicingKaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59.Dual short upstream open reading frames control translation of a herpesviral polycistronic mRNA.Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppressionIdentification of the physiological gene targets of the essential lytic replicative Kaposi's sarcoma-associated herpesvirus ORF57 proteinMechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and ReactivationMolecular biology of KSHV lytic reactivation.Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.Multiple regions of Kaposi's sarcoma-associated herpesvirus ORF59 RNA are required for its expression mediated by viral ORF57 and cellular RBM15.KSHV ORF57, a protein of many facesA novel mechanism inducing genome instability in Kaposi's sarcoma-associated herpesvirus infected cells.Kaposi's sarcoma-associated herpesvirus ORF6 gene is essential in viral lytic replication.Stability of a long noncoding viral RNA depends on a 9-nt core element at the RNA 5' end to interact with viral ORF57 and cellular PABPC1.HITS-CLIP analysis uncovers a link between the Kaposi's sarcoma-associated herpesvirus ORF57 protein and host pre-mRNA metabolismBinding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication.Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta protein.Kaposi's sarcoma-associated herpesvirus ORF57 is not a bona fide export factor.Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation.Kaposi's sarcoma-associated herpesvirus ORF57 functions as a viral splicing factor and promotes expression of intron-containing viral lytic genes in spliceosome-mediated RNA splicing.Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA.Alternative RNA splicing of KSHV ORF57 produces two different RNA isoformsHerpes simplex virus type 1 ICP27 regulates expression of a variant, secreted form of glycoprotein C by an intron retention mechanism.PA-seq for Global Identification of RNA Polyadenylation Sites of Kaposi's Sarcoma-Associated Herpesvirus Transcripts.Genetic disruption of KSHV major latent nuclear antigen LANA enhances viral lytic transcriptional program.Kaposi's sarcoma-associated herpesvirus ORF57 in viral RNA processing.Cell-based screening assay for antiviral compounds targeting the ability of herpesvirus posttranscriptional regulatory proteins to stabilize viral mRNAs.KSHV Rta Promoter Specification and Viral Reactivation.Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis.New insights into the expression and functions of the Kaposi's sarcoma-associated herpesvirus long noncoding PAN RNA.Delineation of a core RNA element required for Kaposi's sarcoma-associated herpesvirus ORF57 binding and activity.Kaposi's sarcoma-associated herpesvirus Rta tetramers make high-affinity interactions with repetitive DNA elements in the Mta promoter to stimulate DNA binding of RBP-Jk/CSL.The cellular peptidyl-prolyl cis/trans isomerase Pin1 regulates reactivation of Kaposi's sarcoma-associated herpesvirus from latencyViral factors reveal a role for REF/Aly in nuclear RNA stability.
P2860
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P2860
Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8.1 and the production of infectious virus.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Targeted disruption of Kaposi' ...... roduction of infectious virus.
@ast
Targeted disruption of Kaposi' ...... roduction of infectious virus.
@en
type
label
Targeted disruption of Kaposi' ...... roduction of infectious virus.
@ast
Targeted disruption of Kaposi' ...... roduction of infectious virus.
@en
prefLabel
Targeted disruption of Kaposi' ...... roduction of infectious virus.
@ast
Targeted disruption of Kaposi' ...... roduction of infectious virus.
@en
P2093
P2860
P356
P1433
P1476
Targeted disruption of Kaposi' ...... roduction of infectious virus.
@en
P2093
J Philip McCoy
Natalia Pripuzova
Vladimir Majerciak
Zhi-Ming Zheng
P2860
P304
P356
10.1128/JVI.01558-06
P407
P577
2006-11-15T00:00:00Z