IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses. - sprookjes - yvandenbroek - TriplyDB

IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses.

IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses.

http://www.wikidata.org/entity/Q35641446

about

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway Regulation of type I interferon responses Small-molecule inhibitors of IκB kinase (IKK) and IKK-related kinases CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation Selective Activation of Type II Interferon Signaling by Zika Virus NS5 Protein.Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data.TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes.Interferon induction and function at the mucosal surface.Signal integration and gene induction by a functionally distinct STAT3 phosphoform.Regulatory evolution of innate immunity through co-option of endogenous retroviruses.Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms.Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth.Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility.The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response.Molecular characterization, expression of chicken TBK1 gene and its effect on IRF3 signaling pathway The pivotal role of TBK1 in inflammatory responses mediated by macrophages The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype STAT2 phosphorylation and signaling.The JAK-STAT pathway at twenty.New insight into the oncogenic mechanism of the retroviral oncoprotein Tax.Hyper activation of β-catenin signalling induced by IKKε inhibition thwarts colorectal cancer cell proliferation.Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity.IKKϵ negatively regulates RIG-I via direct phosphorylation.Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS Positive feedback regulation of type I interferon by the interferon-stimulated gene STING.NF-κB activation coordinated by IKKβ and IKKε enables latent infection of Kaposi's sarcoma-associated herpesvirus.IKKε-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKε.The TRIMendous Role of TRIMs in Virus-Host Interactions.Distal regulatory element of the STAT1 gene potentially mediates positive feedback control of STAT1 expression.IKBKE Is a Substrate of EGFR and a Therapeutic Target in Non-Small Cell Lung Cancer with Activating Mutations of EGFR.Pellino1 is required for interferon production by viral double-stranded RNA.JAK2 V617F stimulates proliferation of erythropoietin-dependent erythroid progenitors and delays their differentiation by activating Stat1 and other nonerythroid signaling pathways.Blimp-1/PRDM1 is a critical regulator of Type III Interferon responses in mammary epithelial cells.Tacrolimus interacts with voriconazole to reduce the severity of fungal keratitis by suppressing IFN-related inflammatory responses and concomitant FK506 and voriconazole treatment suppresses fungal keratitis.NF-κB pathway is involved in CRP-induced effects on pulmonary arterial endothelial cells in chronic thromboembolic pulmonary hypertension.

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P2860

IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses.

http://www.wikidata.org/entity/Q35641446

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

IκB kinase epsilon (IKK(epsilo ...... type II interferon responses.

@ast

IκB kinase epsilon (IKK(epsilo ...... type II interferon responses.

@en

type

label

IκB kinase epsilon (IKK(epsilo ...... type II interferon responses.

@ast

IκB kinase epsilon (IKK(epsilo ...... type II interferon responses.

@en

prefLabel

IκB kinase epsilon (IKK(epsilo ...... type II interferon responses.

@ast

IκB kinase epsilon (IKK(epsilo ...... type II interferon responses.

@en

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PNAS.1119137109

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Proceedings of the National Academy of Sciences of the United States of America

P1476

IκB kinase epsilon (IKK(epsilo ...... type II interferon responses.

@en

P2093

Benjamin R Tenoever

http://www.w3.org/2001/XMLSchema#string

Richard M Myers

http://www.w3.org/2001/XMLSchema#string

Sze-Ling Ng

http://www.w3.org/2001/XMLSchema#string

P2860

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases

IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex

Structural bases of unphosphorylated STAT1 association and receptor binding

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)

Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor

Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

Three-dimensional structure of the Stat3beta homodimer bound to DNA

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

How cells respond to interferons

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21170-21175

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scholarly article

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10.1073/PNAS.1119137109

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52

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108

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51881123

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22171011

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3248534

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