RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating - sprookjes - yvandenbroek - TriplyDB

RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating

RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating

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HIV restriction in quiescent CD4⁺ T cells Fates of retroviral core components during unrestricted and TRIM5-restricted infection Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids.Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α.The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function Functional evidence for the involvement of microtubules and dynein motor complexes in TRIM5α-mediated restriction of retroviruses.Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis.MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1 BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid The fate of HIV-1 capsid: a biochemical assay for HIV-1 uncoating Potent restriction of HIV-1 and SIVmac239 replication by African green monkey TRIM5α.African green monkey TRIM5α restriction in simian immunodeficiency virus-specific rhesus macaque effector CD4 T cells enhances their survival and antiviral function.RING Dimerization Links Higher-Order Assembly of TRIM5α to Synthesis of K63-Linked Polyubiquitin.TRIM5 and the Regulation of HIV-1 Infectivity.Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral properties of TRIM5α.Inhibition of reverse transcriptase activity increases stability of the HIV-1 core.TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization.The maturational refolding of the β-hairpin motif of equine infectious anemia virus capsid protein extends its helix α1 at capsid assembly locus.Host restriction factors in retroviral infection: promises in virus-host interaction.TRIM5α Degradation via Autophagy Is Not Required for Retroviral Restriction.APOBEC3 inhibition of mouse mammary tumor virus infection: the role of cytidine deamination versus inhibition of reverse transcription Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.HIV-1 capsid is involved in post-nuclear entry steps Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex.The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6.An HIV-1 capsid binding protein TRIM11 accelerates viral uncoating.Differential contribution of basic residues to HIV-1 nucleocapsid protein's nucleic acid chaperone function and retroviral replication.HIV-1 uncoating: connection to nuclear entry and regulation by host proteins.TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity.Cyclophilin A potentiates TRIM5α inhibition of HIV-1 nuclear import without promoting TRIM5α binding to the viral capsid.The small-molecule 3G11 inhibits HIV-1 reverse transcription.Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus Retrovirus restriction by TRIM5 proteins requires recognition of only a small fraction of viral capsid subunits.Ubiquitin enzymes in the regulation of immune responses.Characterisation of assembly and ubiquitylation by the RBCC motif of Trim5α HIV-1 Capsid Stabilization Assay.Cytoplasmic dynein promotes HIV-1 uncoating.Human cytosolic extracts stabilize the HIV-1 core A general model for retroviral capsid pattern recognition by TRIM5 proteins.Hijacking of the Ubiquitin/Proteasome Pathway by the HIV Auxiliary Proteins.

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P2860

RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating

http://www.wikidata.org/entity/Q35689590

description

2011 nî lūn-bûn

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

RING domain mutations uncouple ...... and acceleration of uncoating

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RING domain mutations uncouple ...... and acceleration of uncoating

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type

label

RING domain mutations uncouple ...... and acceleration of uncoating

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RING domain mutations uncouple ...... and acceleration of uncoating

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prefLabel

RING domain mutations uncouple ...... and acceleration of uncoating

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RING domain mutations uncouple ...... and acceleration of uncoating

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Journal of Virology

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RING domain mutations uncouple ...... and acceleration of uncoating

@en

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Amanda Roa

http://www.w3.org/2001/XMLSchema#string

Christopher Aiken

http://www.w3.org/2001/XMLSchema#string

Felipe Diaz-Griffero

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Fumiaki Hayashi

http://www.w3.org/2001/XMLSchema#string

Jing Zhou

http://www.w3.org/2001/XMLSchema#string

Jiong Shi

http://www.w3.org/2001/XMLSchema#string

Maritza Lienlaf

http://www.w3.org/2001/XMLSchema#string

Satoru Watanabe

http://www.w3.org/2001/XMLSchema#string

Yang Yang

http://www.w3.org/2001/XMLSchema#string

P2860

TRIM5alpha selectively binds a restriction-sensitive retroviral capsid

The tripartite motif family identifies cell compartments.

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection

Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor

The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities

Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold

Novel Escape Mutants Suggest an Extensive TRIM5α Binding Site Spanning the Entire Outer Surface of the Murine Leukemia Virus Capsid Protein

The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys

Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain

P304

1717-1727

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scholarly article

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10.1128/JVI.05811-11

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P433

3

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P478

86

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Shigeyuki Yokoyama

Takanori Kigawa

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2011-11-23T00:00:00Z

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22114335

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3264337

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