N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD
about
An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decayRibosome-based quality control of mRNA and nascent peptidesNonsense-mediated mRNA decay: novel mechanistic insights and biological impactMechanism and regulation of the nonsense-mediated decay pathwayThe dharma of nonsense-mediated mRNA decay in mammalian cellsNonsense-mediated mRNA decay: inter-individual variability and human diseaseStructural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6Nonsense-mediated mRNA decay in humans at a glanceNonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryOrganizing principles of mammalian nonsense-mediated mRNA decayAttenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppressionMutations in SMG9, Encoding an Essential Component of Nonsense-Mediated Decay Machinery, Cause a Multiple Congenital Anomaly Syndrome in Humans and MiceIn Silico Analysis of the Structural and Biochemical Features of the NMD Factor UPF1 in Ustilago maydisHIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.High-resolution profiling of NMD targets in yeast reveals translational fidelity as a basis for substrate selection.Identification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutationsMultifaceted Regulation of Gene Expression by the Apoptosis- and Splicing-Associated Protein Complex and Its Components.A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.A post-translational regulatory switch on UPF1 controls targeted mRNA degradationEmerging roles for ribonucleoprotein modification and remodeling in controlling RNA fateThe interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay.5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes.Nonsense-mediated decay in genetic disease: friend or foe?MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1.Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells.SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA.Structural basis for regulation of RNA-binding proteins by phosphorylation.Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics.Regulation of cytoplasmic mRNA decay.A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylationLong noncoding RNA turnover.MicroRNA 433 regulates nonsense-mediated mRNA decay by targeting SMG5 mRNA.Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay.Nonsense-mediated mRNA decay in Tetrahymena is EJC independent and requires a protozoa-specific nucleaseTarget Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase ActivityRecent transcriptome-wide mapping of UPF1 binding sites reveals evidence for its recruitment to mRNA before translation.SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay.
P2860
Q24311198-C4A56BC1-8D23-45F1-A89A-A51C995E3679Q26748589-68814696-7770-4E46-851C-320ED4478BA6Q26750271-2EC9FC7B-E207-4466-90F1-A0F7AE3DBF3FQ26771669-9C06B2DE-FF60-4709-A6BE-1AF513C30FD7Q27014757-307FB4F8-8573-42EA-BA07-CC6851BE5732Q27015298-8C94B019-B762-4DA5-83D2-666E690D7E4AQ27680677-53E22276-0C30-425F-8802-3F2876C4D866Q27684654-F6C024C2-7711-4D63-9C31-E9CC6FEBFE5EQ28077157-3FAD9938-FE5E-471B-931F-EB4AE28CF2EBQ28082699-AE3B73D2-B071-41CC-84E4-CBDEAE2F795EQ28302705-FB1DB97E-1917-4E58-A679-B5EE1C7083AAQ28486134-614D41DE-BFE8-44D0-82DC-3163F520110FQ28513439-F04EF0E7-E5C6-478C-AEC0-73FC0EA33C9EQ28550086-1DC0D6F5-F99C-4D8E-ABD3-43789F14D9CDQ30488459-C3366A0C-8AA9-4916-957C-F11851F0B470Q33569251-6487AB64-6645-4196-8301-6924BF43C472Q33693359-EAD865E5-7F67-4E05-B1B1-51323ED8D155Q33717750-84EE1013-4ED1-4255-BDD5-D6B2BB4A1D0DQ34044484-59B9C764-3BF3-4858-AFF9-F1E3A0F31512Q34342871-802C8E47-794E-4D9D-8E1F-20D3EA86E048Q34350089-FCF908D8-A2EF-43D5-937E-4300EDC363F7Q34434530-5D484451-FB82-4784-8668-8DF48EC47D1CQ34443734-F5F0A835-078E-4824-B760-D2F999FE74DFQ34518964-4ACBC69A-2ED6-4A82-A2AF-6DDE75AF205DQ34658988-2C5B6112-0A64-45DE-BFBA-B7BB66DFF41BQ34797975-5E13E2D2-3B46-4FC0-ABEF-1C7AD6AD83C2Q34883031-E841BBDB-49A9-4CF3-8B7D-CE38D47EA25BQ35005149-3ADBD3F8-3309-41F9-BFF2-88BCF5BC80EDQ35213072-CE97C7A0-B732-4CF3-BAA1-B61CAA12C4C1Q35222320-C574650C-3859-4C1A-AB9D-155F8684D408Q35955726-5CA9EED1-8AAC-42B2-A7F9-00B28EF8C420Q36002424-04DB5CC4-624C-496C-8DCE-C8F9D9AC7FFBQ36048203-62E6A1AD-7424-4F77-BCF9-BF0E1CDBDE95Q36090334-E466B33C-5083-403C-BD9C-5DA4D494BA5AQ36114054-363BCD4D-EABF-4CA3-8550-E3C1A1C23454Q36316534-61E89919-6B66-44B7-9377-58A4251CC3B0Q36344535-C76C3B3A-5265-4851-B8FE-156700B8C5B4Q36358461-24A10239-D089-48FB-8EA5-FF4B4D36B732Q36477524-7DF373B4-D7B7-46DA-AF24-6E6F934EECACQ36559295-5453D12C-FCD8-4631-B844-3ED9910E2694
P2860
N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD
@ast
N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD
@en
type
label
N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD
@ast
N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD
@en
prefLabel
N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD
@ast
N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD
@en
P2093
P2860
P356
P1476
N- and C-terminal Upf1 phospho ...... G-6 and SMG-5:SMG-7 during NMD
@en
P2093
Akio Yamashita
Fumiki Hirahara
Kei Kutsuzawa
Natsuko Izumi
Yukiko Okada-Katsuhata
P2860
P304
P356
10.1093/NAR/GKR791
P407
P50
P577
2011-09-29T00:00:00Z