Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death.
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Inside out: the role of nucleocytoplasmic transport in ALS and FTLDInteraction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicityLoss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromesFormation and spreading of TDP-43 aggregates in cultured neuronal and glial cells demonstrated by time-lapse imaging.HuR-Dependent Editing of a New Mineralocorticoid Receptor Splice Variant Reveals an Osmoregulatory Loop for Sodium HomeostasisTruncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variantStructural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation.An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic miceThe chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity.TDP-43/FUS in motor neuron disease: Complexity and challenges.Fluid-Based Biomarkers for Amyotrophic Lateral Sclerosis.Human Endogenous Retrovirus-K and TDP-43 Expression Bridges ALS and HIV Neuropathology.Cost-effective elimination of lipofuscin fluorescence from formalin-fixed brain tissue by white phosphor light emitting diode array.MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis.Pathomechanisms of TDP-43 in neurodegeneration.TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis.RNA-Binding Proteins in Amyotrophic Lateral SclerosisTdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells
P2860
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P2860
Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Low molecular weight species o ...... result in motor neuron death.
@ast
Low molecular weight species o ...... result in motor neuron death.
@en
type
label
Low molecular weight species o ...... result in motor neuron death.
@ast
Low molecular weight species o ...... result in motor neuron death.
@en
prefLabel
Low molecular weight species o ...... result in motor neuron death.
@ast
Low molecular weight species o ...... result in motor neuron death.
@en
P2093
P2860
P1476
Low molecular weight species o ...... d result in motor neuron death
@en
P2093
Ekaterina Rogaeva
Helen Chiang
Janice Robertson
Julia Keith
Lorne Zinman
Shangxi Xiao
Teresa Sanelli
P2860
P2888
P356
10.1007/S00401-015-1412-5
P577
2015-03-19T00:00:00Z