Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity.
about
Microtubule plus-end tracking proteins in neuronal developmentToggling a conformational switch in Wnt/β-catenin signaling: regulation of Axin phosphorylation. The phosphorylation state of Axin controls its scaffold function in two Wnt pathway protein complexesGSK-3 as potential target for therapeutic intervention in cancerThe β-catenin destruction complexRole of the beta catenin destruction complex in mediating chemotherapy-induced senescence-associated secretory phenotypedifferent Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coliA metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes.Colorectal polyps and polyposis syndromesThe Wnt/β-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target.Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities.Phosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse IntestineReversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex.Frizzled and LRP5/6 receptors for Wnt/β-catenin signalingHectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.Wnt pathway activation by ADP-ribosylation.Proteomic analysis reveals APC-dependent post-translational modifications and identifies a novel regulator of β-catenin.Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish.Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseasesWnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.Wnt Signaling in Normal and Malignant Stem Cells.Molecular regulation and pharmacological targeting of the β-catenin destruction complex.Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies.MiRNAs in Astrocyte-Derived Exosomes as Possible Mediators of Neuronal Plasticity.Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing.Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells.The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of β-catenin, a GSK3 substrate, in human glioblastoma cells.Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC.Inhibition of TGFβ signaling promotes ground state pluripotency.Nuclear GSK-3β segregation in desmoid-type fibromatosis.
P2860
Q26766239-4E6467A3-BBEB-4DAF-8432-C5BE473EFCF4Q26829995-A782B3D3-52B2-4D57-8905-70F4D3D271E9Q27013811-9BA42E39-A6A0-46CC-AD7C-E2F042E47562Q28279593-09248974-F271-42F2-8B99-9D81BDD23EAEQ28484422-832A769E-3137-4D9E-AE48-524A6826B05FQ28537734-C12A126D-0D14-466F-BC84-8FF3F34C591DQ33554605-9D25B017-9DD9-48CC-9969-CE9052CAA2BAQ34589148-6CCC337A-CB7F-42D2-92D4-825EFECF35B3Q34661470-07B33C92-AF91-4EED-A46E-45A96F6C1230Q34670501-F78D268C-BE7B-48EA-9356-30ED8E7EC4D9Q35165279-A6EB0A2B-1E10-464B-8755-EA36330BBB1AQ36048048-CFEDF0D9-7B07-4082-BD77-4B4E9D565D6EQ36217192-3C4D40E2-6FE2-41EE-A439-A3F17C2E0EDEQ36418023-1B9D30F0-097D-4FB7-ABA0-26169C5B6BB0Q36596124-187969B2-B6AE-435D-A605-36C763D59CFBQ36850827-30563086-84E1-4630-9BF8-8167CC04DD77Q36871744-6FD67F00-99AB-4978-A9B9-5A9F77571EDDQ37120482-446A06EB-A22F-4D6C-84D8-0A6BDAEA6447Q37438495-9E940CA5-9627-4ADA-B98C-33FA6C25E4BDQ37460101-8BD86B80-A3E4-48E1-A8BF-0FF84E4EC8BFQ38272835-D2189341-6B86-4633-818F-5685AE63C15BQ38807957-72D31CDB-39BE-4669-BB79-4EA4DE9E7139Q39306017-16138172-87BD-4402-BB89-B182838EF3E8Q39387545-89775209-8586-4F65-BCF8-855412EA5F1CQ41832911-FDE0751E-46DD-4ACB-925F-CA67800CC9BDQ41997354-0D788892-A809-476C-923C-4BA4361FBE83Q42777723-709869B7-A6D4-41E6-B266-4EE205121CEDQ46140977-A2CE65AA-7B5D-49C7-BB88-4AF9BF8F2B13Q47322400-B5FDA44D-760A-4B49-B866-B52383C9DEEFQ48097856-14D080A2-FDAD-43DE-879A-684E901620DBQ50721932-20DA5E38-5C4D-4B4F-A4B1-72278B773080Q51045139-D59A86FC-223C-4717-BDE6-C09577FD467F
P2860
Adenomatous polyposis coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Adenomatous polyposis coli (AP ...... ase kinase-3 (GSK-3) activity.
@ast
Adenomatous polyposis coli (AP ...... ase kinase-3 (GSK-3) activity.
@en
type
label
Adenomatous polyposis coli (AP ...... ase kinase-3 (GSK-3) activity.
@ast
Adenomatous polyposis coli (AP ...... ase kinase-3 (GSK-3) activity.
@en
prefLabel
Adenomatous polyposis coli (AP ...... ase kinase-3 (GSK-3) activity.
@ast
Adenomatous polyposis coli (AP ...... ase kinase-3 (GSK-3) activity.
@en
P2093
P2860
P356
P1476
Adenomatous polyposis coli (AP ...... ase kinase-3 (GSK-3) activity.
@en
P2093
Alexander J Valvezan
Fang Zhang
J Alan Diehl
Peter S Klein
P2860
P304
P356
10.1074/JBC.M111.323337
P407
P577
2011-12-19T00:00:00Z