Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals.
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The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogsTenofovir renal toxicity targets mitochondria of renal proximal tubules.Loss of hepatic DEPTOR alters the metabolic transition to fastingTransgenic cardiac-targeted overexpression of human thymidylate kinaseTenofovir renal proximal tubular toxicity is regulated by OAT1 and MRP4 transportersRibonucleotide reductase is not limiting for mitochondrial DNA copy number in mice.High-resolution genomic profiling of thyroid lesions uncovers preferential copy number gains affecting mitochondrial biogenesis loci in the oncocytic variants.Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation.Detection of differentially methylated gene promoters in failing and nonfailing human left ventricle myocardium using computation analysis.Mouse models of mitochondrial DNA defects and their relevance for human disease.Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation.Mitochondrial DNA impairment in nucleoside reverse transcriptase inhibitor-associated cardiomyopathyCardiac-targeted transgenic mutant mitochondrial enzymes: mtDNA defects, antiretroviral toxicity and cardiomyopathy.Mitochondrial purine and pyrimidine metabolism and beyond.Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis.Beyond the polymerase-γ theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity.
P2860
Q28565523-F51A33CB-F4AC-4319-890A-F2C8FF5B76CBQ33416391-8EBAC97D-3970-458A-A72F-61C8B0A201F3Q33600500-D386F162-1193-430D-9BA7-F15480DB27D2Q33690295-FA35470C-7AAB-4580-A6C0-0F82ACFCE82CQ33845879-B61E70F1-225A-474D-809D-2CE02591AF4FQ34401495-85AE203B-7AA5-4368-9964-E8FE31FB7114Q35929824-F818DC8D-1603-471E-8638-7EA220AD8030Q37054681-DD8F4B5F-A39E-4483-A485-246F7602BE50Q37054691-996497F2-836A-4EE5-9422-F0BAEDA84E5CQ37087221-C8B249B1-FBDB-49F1-B7D0-CD58C43F29F7Q37199813-A3B20C73-04D2-4758-8C2B-2FF7C204D18AQ37239515-B02B1B21-A086-457E-8C1D-21C8E8C09C17Q37239825-5E09F14C-333A-4E3E-B80B-E058B6D133A2Q39025697-B6AA2D21-C94D-4DD7-BE8F-47E961211F75Q41940970-EA9B9F41-FAFE-42C3-8705-98694A68ED47Q44797235-A2C1DD66-B6D3-480C-8541-2F60BA1A122B
P2860
Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Targeted transgenic overexpres ...... 2, mtDNA, and antiretrovirals.
@ast
Targeted transgenic overexpres ...... 2, mtDNA, and antiretrovirals.
@en
type
label
Targeted transgenic overexpres ...... 2, mtDNA, and antiretrovirals.
@ast
Targeted transgenic overexpres ...... 2, mtDNA, and antiretrovirals.
@en
prefLabel
Targeted transgenic overexpres ...... 2, mtDNA, and antiretrovirals.
@ast
Targeted transgenic overexpres ...... 2, mtDNA, and antiretrovirals.
@en
P2093
P2860
P1476
Targeted transgenic overexpres ...... 2, mtDNA, and antiretrovirals.
@en
P2093
Chad P Haase
Elgin Green
Erin Keebaugh
James J Kohler
Nina Tioleco
Robert Long
Rodney Russ
Seyed H Hosseini
Staffan Eriksson
P2860
P304
P356
10.2353/AJPATH.2007.060655
P407
P577
2007-03-01T00:00:00Z