about
Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Mechanisms of small-molecule binding to intrinsically disordered proteins.Identification and characterization of a compound from Cuminum cyminum essential oil with antifibrilation and cytotoxic effectDiscovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1).Z-Phe-Ala-diazomethylketone (PADK) disrupts and remodels early oligomer states of the Alzheimer disease Aβ42 protein.Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling.Induced Dipole-Dipole Interactions Influence the Unfolding Pathways of Wild-Type and Mutant Amyloid β-Peptides.The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's diseaseMethods of probing the interactions between small molecules and disordered proteins.Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid β.Combined experimental and simulation studies suggest a revised mode of action of the anti-Alzheimer disease drug NQ-Trp.Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide.Effects of Zn2+ binding on the structural and dynamic properties of amyloid β peptide associated with Alzheimer's disease: Asp1 or Glu11?Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity.Molecular interactions of Alzheimer's biomarker FDDNP with Aβ peptide.Temperature dependence of Congo red binding to amyloid β12-28.The ATAD2 bromodomain binds different acetylation marks on the histone H4 in similar fuzzy complexes.A Small Molecule Causes a Population Shift in the Conformational Landscape of an Intrinsically Disordered Protein.Carnosine inhibits Aβ(42) aggregation by perturbing the H-bond network in and around the central hydrophobic cluster.
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Disordered binding of small molecules to Aβ(12-28).
@ast
Disordered binding of small molecules to Aβ(12-28).
@en
type
label
Disordered binding of small molecules to Aβ(12-28).
@ast
Disordered binding of small molecules to Aβ(12-28).
@en
prefLabel
Disordered binding of small molecules to Aβ(12-28).
@ast
Disordered binding of small molecules to Aβ(12-28).
@en
P2093
P2860
P356
P1476
Disordered binding of small molecules to Aβ(12-28).
@en
P2093
Amedeo Caflisch
Andreas Vitalis
Marino Convertino
P2860
P304
41578-41588
P356
10.1074/JBC.M111.285957
P407
P577
2011-10-03T00:00:00Z