Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds
about
Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death.A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds.Heterozygous mutation of cysteine528 in XPO1 is sufficient for resistance to selective inhibitors of nuclear exportXPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose.
P2860
Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds
description
2015 nî lūn-bûn
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2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
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name
Deciphering mechanisms of drug ...... uclear Export (SINE) compounds
@ast
Deciphering mechanisms of drug ...... uclear Export (SINE) compounds
@en
type
label
Deciphering mechanisms of drug ...... uclear Export (SINE) compounds
@ast
Deciphering mechanisms of drug ...... uclear Export (SINE) compounds
@en
prefLabel
Deciphering mechanisms of drug ...... uclear Export (SINE) compounds
@ast
Deciphering mechanisms of drug ...... uclear Export (SINE) compounds
@en
P2093
P2860
P1433
P1476
Deciphering mechanisms of drug ...... uclear Export (SINE) compounds
@en
P2093
Boris Klebanov
Jean-Richard Saint-Martin
Marsha Crochiere
Sharon Shechter
Trinayan Kashyap
William Senapedis
Yosef Landesman
P2860
P2888
P356
10.1186/S12885-015-1790-Z
P407
P577
2015-11-17T00:00:00Z
P6179
1033733422