Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques
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C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling.Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegiaTrehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural ActivityLysosomes relax in the cellular suburbs.Compartment-Specific Regulation of Autophagy in Primary Neurons.Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.Progranulin, lysosomal regulation and neurodegenerative disease.Study of Exosomes Shed New Light on Physiology of Amyloidogenesis.Mechanisms of neuronal homeostasis: Autophagy in the axon.A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds.Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes.C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease.Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.A Comparison of Lysosomal Enzymes Expression Levels in Peripheral Blood of Mild- and Severe-Alzheimer's Disease and MCI Patients: Implications for Regenerative Medicine Approaches.Commentary: Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient miceBORC/kinesin-1 ensemble drives polarized transport of lysosomes into the axon.Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia.Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.The Role of Cerebrovascular Disease in Amyloid Deposition.Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis.Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology.Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease.Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer's disease neurons.Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1.The where, what, and when of membrane protein degradation in neurons.Progranulin increases phagocytosis by retinal pigment epithelial cells in culture.Heat Shock Proteins and Autophagy Pathways in Neuroprotection: from Molecular Bases to Pharmacological Interventions.Compartment-specific dynamics and functions of autophagy in neurons.Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.Identification of Sidt2 as a lysosomal cation-conducting protein.Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques.Neuronal lysosomes.Axonal transport and maturation of lysosomes.Sphingosine kinase 1-associated autophagy differs between neurons and astrocytes.
P2860
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P2860
Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Massive accumulation of lumina ...... imer's disease amyloid plaques
@ast
Massive accumulation of lumina ...... imer's disease amyloid plaques
@en
type
label
Massive accumulation of lumina ...... imer's disease amyloid plaques
@ast
Massive accumulation of lumina ...... imer's disease amyloid plaques
@en
prefLabel
Massive accumulation of lumina ...... imer's disease amyloid plaques
@ast
Massive accumulation of lumina ...... imer's disease amyloid plaques
@en
P2093
P2860
P356
P1476
Massive accumulation of lumina ...... imer's disease amyloid plaques
@en
P2093
Jaime Grutzendler
Matthew Schrag
Shawn M Ferguson
Summer Paradise
Swetha Gowrishankar
P2860
P304
P356
10.1073/PNAS.1510329112
P407
P577
2015-06-29T00:00:00Z