An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus
about
Enhancer complexes located downstream of both human immunoglobulin Calpha genesThe HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombinationPosition and sequence conservation in Amniota of polymorphic enhancer HS1.2 within the palindrome of IgH 3'Regulatory RegionLong-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombinationIdentification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer.AID and somatic hypermutation.Human antibodies from transgenic mice.Transgenes of the mouse immunoglobulin heavy chain locus, lacking distal elements in the 3' regulatory region, are impaired for class switch recombinationIdentification of 3' alpha-hs4, a novel Ig heavy chain enhancer element regulated at multiple stages of B cell differentiation.Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.Accessibility control and machinery of immunoglobulin class switch recombination.Homologous elements hs3a and hs3b in the 3' regulatory region of the murine immunoglobulin heavy chain (Igh) locus are both dispensable for class-switch recombination.Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching.Enhancement of antibody class-switch recombination by the cumulative activity of four separate elements.Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancersCritical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci.The 3' end of the heavy chain constant region locus enhances germline transcription and switch recombination of the four gamma genes.Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.Regulation of the replication of the murine immunoglobulin heavy chain gene locus: evaluation of the role of the 3' regulatory region.ERP, a new member of the ets transcription factor/oncoprotein family: cloning, characterization, and differential expression during B-lymphocyte development.Transcription of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3' regulatory regionIn a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development.Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.Concerted repression of an immunoglobulin heavy-chain enhancer, 3' alpha E(hs1,2)Epigenetic Regulation of Individual Modules of the immunoglobulin heavy chain locus 3' Regulatory Region.Identification of Ets-like lymphoid specific elements within the immunoglobulin heavy chain 3' enhancer.Role of defective Oct-2 and OCA-B expression in immunoglobulin production and Kaposi's sarcoma-associated herpesvirus lytic reactivation in primary effusion lymphoma.An analysis of genes regulated by the multi-functional transcriptional regulator Yin Yang-1.Pi, a pre-B-cell-specific enhancer element in the immunoglobulin heavy-chain enhancer.IgM receptor-mediated transactivation of the IgH 3' enhancer couples a novel Elf-1-AP-1 protein complex to the developmental control of enhancer function.Deletional analyses reveal an essential role for the hs3b/hs4 IgH 3' enhancer pair in an Ig-secreting but not an earlier-stage B cell line.V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3' enhancer.Regulation of promoter and intron enhancer activity in immunoglobulin heavy-chain genes during B-cell differentiation.Hypothesis: biological role for J-C intronic matrix attachment regions in the molecular mechanism of antigen-driven somatic hypermutation.The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination
P2860
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P2860
An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus
@ast
An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus
@en
type
label
An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus
@ast
An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus
@en
prefLabel
An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus
@ast
An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus
@en
P2093
P2860
P356
P1476
An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus
@en
P2093
B K Birshtein
L A Eckhardt
R Lieberson
S L Giannini
P2860
P304
P356
10.1093/NAR/19.4.933
P407
P577
1991-02-01T00:00:00Z