The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma
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Silencing Mist1 Gene Expression Is Essential for Recovery from Acute PancreatitisTherapeutic potential of targeting acinar cell reprogramming in pancreatic cancerRegulation of Cellular Identity in CancerA rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics.Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style.Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation.Early pancreatic islet fate and maturation is controlled through RBP-JκTGF-β1 promotes acinar to ductal metaplasia of human pancreatic acinar cells.MIST1 and PTF1 Collaborate in Feed-forward Regulatory Loops that Maintain the Pancreatic Acinar Phenotype in Adult Mice.PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.Acinar cell plasticity and development of pancreatic ductal adenocarcinoma.Differentiation and Inflammation: 'Best Enemies' in Gastrointestinal Carcinogenesis.Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer.Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A.Slug inhibits pancreatic cancer initiation by blocking Kras-induced acinar-ductal metaplasiaChange isn't always better.Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells.Activating transcription factor 3 promotes loss of the acinar cell phenotype in response to cerulein-induced pancreatitis in mice.Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice.Malnutrition in Pancreatic Ductal Adenocarcinoma (PDA): Dietary Pancreatic Enzymes Improve Short-Term Health but Stimulate Tumor Growth.Understanding Disease Biology and Informing the Management of Pancreas Cancer With Preclinical Model Systems.ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis.Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact.In vivo reprogramming drives Kras-induced cancer development.Induced PTF1a expression in pancreatic ductal adenocarcinoma cells activates acinar gene networks, reduces tumorigenic properties, and sensitizes cells to gemcitabine treatment.E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4A and Wild-Type p53.Arid1a restrains Kras-dependent changes in acinar cell identity.The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesisPtf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway
P2860
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P2860
The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
The acinar differentiation det ...... ncreatic ductal adenocarcinoma
@ast
The acinar differentiation det ...... ncreatic ductal adenocarcinoma
@en
type
label
The acinar differentiation det ...... ncreatic ductal adenocarcinoma
@ast
The acinar differentiation det ...... ncreatic ductal adenocarcinoma
@en
prefLabel
The acinar differentiation det ...... ncreatic ductal adenocarcinoma
@ast
The acinar differentiation det ...... ncreatic ductal adenocarcinoma
@en
P2093
P2860
P356
P1433
P1476
The acinar differentiation det ...... ncreatic ductal adenocarcinoma
@en
P2093
Chinh Q Hoang
Christopher Ve Wright
Fong Chen Pan
Gabriela M Cash
Galvin H Swift
Jean-Paul De La O
L Charles Murtaugh
Mary P Bronner
Nathan M Krah
Raymond J MacDonald
P2860
P356
10.7554/ELIFE.07125
P407
P577
2015-07-07T00:00:00Z