Lipid rafts are required for Kit survival and proliferation signals
about
Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasmsCD45 phosphatase is crucial for human and murine acute myeloid leukemia maintenance through its localization in lipid raftsInhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse.Interaction between activated chemokine receptor 1 and FcepsilonRI at membrane rafts promotes communication and F-actin-rich cytoneme extensions between mast cells.The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recyclingEffect of plasma membrane cholesterol depletion on glucose transport regulation in leukemia cellsClathrin assembly protein CALM plays a critical role in KIT signaling by regulating its cellular transport from early to late endosomes in hematopoietic cells.Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation.PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains.PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeabilityAnalysis of lipid-composition changes in plasma membrane microdomainsLipid rafts and caveolae in signaling by growth factor receptors.ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression.The tyrosine kinase network regulating mast cell activation.New insights on mast cell activation via the high affinity receptor for IgEWiskott-Aldrich syndrome protein is an effector of Kit signaling.Complex chemoattractive and chemorepellent Kit signals revealed by direct imaging of murine mast cells in microfluidic gradient chambers.RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells.Membrane lipid rafts, master regulators of hematopoietic stem cell retention in bone marrow and their trafficking.Lipid rafts couple store-operated Ca2+ entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth.Effects of endoplasmic reticulum stressors on maturation and signaling of hemizygous and heterozygous wild-type and mutant forms of KIT.Direct interaction between Kit and the interleukin-7 receptor.Low level of c-kit expression marks deeply quiescent murine hematopoietic stem cells.
P2860
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P2860
Lipid rafts are required for Kit survival and proliferation signals
description
2007 nî lūn-bûn
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年论文
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2007年论文
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2007年论文
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name
Lipid rafts are required for Kit survival and proliferation signals
@ast
Lipid rafts are required for Kit survival and proliferation signals
@en
type
label
Lipid rafts are required for Kit survival and proliferation signals
@ast
Lipid rafts are required for Kit survival and proliferation signals
@en
prefLabel
Lipid rafts are required for Kit survival and proliferation signals
@ast
Lipid rafts are required for Kit survival and proliferation signals
@en
P2093
P2860
P1433
P1476
Lipid rafts are required for Kit survival and proliferation signals
@en
P2093
Erica Leifheit
Kenneth Weinberg
Simran Sindhu
Stacie Gooch
Thomas Jahn
P2860
P304
P356
10.1182/BLOOD-2006-05-020925
P407
P577
2007-06-06T00:00:00Z