Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells - sprookjes - yvandenbroek - TriplyDB

Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells

Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells

http://www.wikidata.org/entity/Q36054977

about

Mutant p53: One, No One, and One Hundred Thousand Chk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell death Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970 Development of synthetic lethality anticancer therapeutics.Combined CDKN1A/TP53 mutation in bladder cancer is a therapeutic target.YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1.Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines The ATM signaling network in development and disease.Translational and clinical implications of the genetic landscape of prostate cancer.A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.The cell cycle checkpoint inhibitors in the treatment of leukemias.Targeted inhibition of ATR or CHEK1 reverses radioresistance in oral squamous cell carcinoma cells with distal chromosome arm 11q loss.Molecularly targeted therapies for p53-mutant cancers.Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells A pool of peptides extracted from wheat bud chromatin inhibits tumor cell growth by causing defective DNA synthesis.From breaking bad to worse: exploiting homologous DNA repair deficiency in cancer.Candidate synthetic lethality partners to PARP inhibitors in the treatment of ovarian clear cell cancer.HUS1 regulates in vivo responses to genotoxic chemotherapies.Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models.Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model.

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P2860

Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells

http://www.wikidata.org/entity/Q36054977

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P2860

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

CDK inhibitors: positive and negative regulators of G1-phase progression

Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint

p21 is necessary for the p53-mediated G1 arrest in human cancer cells

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

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