Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration - sprookjes - yvandenbroek - TriplyDB

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

http://www.wikidata.org/entity/Q36057587

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The Photobiology of Lutein and Zeaxanthin in the Eye Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration.Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy.Interferon-beta signaling in retinal mononuclear phagocytes attenuates pathological neovascularization.Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling.Targeting translocator protein (18 kDa) (TSPO) dampens pro-inflammatory microglia reactivity in the retina and protects from degeneration.DYNAMISM OF DOT SUBRETINAL DRUSENOID DEPOSITS IN AGE-RELATED MACULAR DEGENERATION DEMONSTRATED WITH ADAPTIVE OPTICS IMAGING.Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration Strong upregulation of inflammatory genes accompanies photoreceptor demise in canine models of retinal degeneration.C-Reactive protein and progression of vision loss in retinitis pigmentosa.Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina.The broad-spectrum chemokine inhibitor NR58-3.14.3 modulates macrophage-mediated inflammation in the diseased retina.Gene expression changes in the retina following subretinal injection of human neural progenitor cells into a rodent model for retinal degeneration.Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina.Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration.Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration.The natural retinoprotectant chrysophanol attenuated photoreceptor cell apoptosis in an N-methyl-N-nitrosourea-induced mouse model of retinal degenaration.Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina.Early Events in Retinal Degeneration Caused by Rhodopsin Mutation or Pigment Epithelium Malfunction: Differences and Similarities.Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration.HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo.Comprehensive analysis of mouse retinal mononuclear phagocytes.Friend or Foe? Resident Microglia vs Bone Marrow-Derived Microglia and Their Roles in the Retinal Degeneration.Potassium channel expression and function in microglia: Plasticity and possible species variations.Macrophage physiology in the eye.New insights into mononuclear phagocyte biology from the visual system.The IL-1β phenomena in neuroinflammatory diseases.Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina.Persistent inflammatory state after photoreceptor loss in an animal model of retinal degeneration.MUTYH promotes oxidative microglial activation and inherited retinal degeneration.Monocyte infiltration and proliferation reestablish myeloid cell homeostasis in the mouse retina following retinal pigment epithelial cell injury.Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration.Tamoxifen Provides Structural and Functional Rescue in Murine Models of Photoreceptor Degeneration.Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa.Live-cell imaging: new avenues to investigate retinal regeneration.Culture of Adult Transgenic Zebrafish Retinal Explants for Live-cell Imaging by Multiphoton Microscopy.Microglial-induced Müller cell gliosis is attenuated by progesterone in a mouse model of retinitis pigmentosa.A subpopulation of activated retinal macrophages selectively migrated to regions of cone photoreceptor stress, but had limited effect on cone death in a mouse model for type 2 Leber congenital amaurosis.

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Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration

http://www.wikidata.org/entity/Q36057587

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2015 nî lūn-bûn

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name

Microglial phagocytosis of liv ...... inherited retinal degeneration

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Microglial phagocytosis of liv ...... inherited retinal degeneration

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Microglial phagocytosis of liv ...... inherited retinal degeneration

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Microglial phagocytosis of liv ...... inherited retinal degeneration

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EMBO Molecular Medicine

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Microglial phagocytosis of liv ...... inherited retinal degeneration

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Christopher N Parkhurst

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Haohua Qian

http://www.w3.org/2001/XMLSchema#string

Matthew K Zabel

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Parth Shah

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Robert N Fariss

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Wen-Biao Gan

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Xu Wang

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P2860

Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment

Safety and efficacy of gene transfer for Leber's congenital amaurosis

Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission

Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members

Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death

Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina

Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning

Retinitis pigmentosa

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

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1179-1197

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10.15252/EMMM.201505298

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9

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26139610

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Photoreceptor protein

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4568951

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