Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure.
about
Three-Dimensional Structure and Orientation of Rat Islet Amyloid Polypeptide Protein in a Membrane Environment by Solution NMR SpectroscopyConstraining cyclic peptides to mimic protein structure motifs.4R- and 4S-iodophenyl hydroxyproline, 4R-pentynoyl hydroxyproline, and S-propargyl-4-thiolphenylalanine: conformationally biased and tunable amino acids for bioorthogonal reactions.Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptorsThe combination of prolinoamino acids and cyclopropylamino acids leads to fully functionalized, stable β-turns in water.Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactionsEndothelin-A receptor antagonism attenuates carcinoma-induced pain through opioids in mice.Application of a sequential multicomponent assembly process/huisgen cycloaddition strategy to the preparation of libraries of 1,2,3-triazole-fused 1,4-benzodiazepines.Synthesis and conformational studies of peptido-squaramide foldable modules: a new class of turn-mimetic compounds.Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.Synthesis of rhenium-centric reverse turn mimics.Pathway-selective antagonism of proteinase activated receptor 2.Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptorsThe identification of high-affinity G protein-coupled receptor ligands from large combinatorial libraries using multicolor quantum dot-labeled cell-based screening.Cone snail venomics: from novel biology to novel therapeutics.Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphinsUterotonic plants and their bioactive constituentsSolid-phase synthesis, cyclization, and site-specific functionalization of aziridine-containing tetrapeptides.Chemistry and biology of multicomponent reactions.Privileged scaffolds targeting reverse-turn and helix recognition.Headgroup-dependent membrane catalysis of apelin-receptor interactions is likely.Use of secondary structure element information in drug design: polypharmacology and conserved motifs in protein-ligand binding and protein-protein interfaces.Synthesis, structure, and biological applications of α-fluorinated β-amino acids and derivatives.3-Substituted prolines: from synthesis to structural applications, from peptides to foldamers.Medicinal significance of naturally occurring cyclotetrapeptides.Exploiting cancer's phenotypic guise against itself: targeting ectopically expressed peptide G-protein coupled receptors for lung cancer therapy.On the terminal homologation of physiologically active peptides as a means of increasing stability in human serum--neurotensin, opiorphin, B27-KK10 epitope, NPY.Exploring the Backbone of Enkephalins To Adjust Their Pharmacological Profile for the δ-Opioid Receptor.Design and synthesis of Hsp90 inhibitors: exploring the SAR of Sansalvamide A derivatives.Amide-to-ester substitution allows fine-tuning of the cyclopeptide conformational ensemble.A comprehensive study of Sansalvamide A derivatives: The structure-activity relationships of 78 derivatives in two pancreatic cancer cell lines.Proline editing: a general and practical approach to the synthesis of functionally and structurally diverse peptides. Analysis of steric versus stereoelectronic effects of 4-substituted prolines on conformation within peptides.Syntheses, receptor bindings, in vitro and in vivo stabilities and biodistributions of DOTA-neurotensin(8-13) derivatives containing β-amino acid residues - a lesson about the importance of animal experiments.In-peptide synthesis of di-oxazolidinone and dehydroamino acid-oxazolidinone motifs as β-turn inducers.Ester vs. amide on folding: a case study with a 2-residue synthetic peptide.The Staudinger reaction with 2-imino-1,3-thiaselenanes toward the synthesis of C4 spiro-β-lactams.Limiting Assumptions in the Design of Peptidomimetics.Quaternary β2,2 -Amino Acids: Catalytic Asymmetric Synthesis and Incorporation into Peptides by Fmoc-Based Solid-Phase Peptide Synthesis.Oxadiazole grafts in peptide macrocycles.Two Opposing d-Amino Acids Give Zigzag Hairpin Epitopes an Additional Kink to Create Antibody-Selective Peptide Antigens.
P2860
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P2860
Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Over one hundred peptide-activ ...... e ligands with turn structure.
@ast
Over one hundred peptide-activ ...... e ligands with turn structure.
@en
type
label
Over one hundred peptide-activ ...... e ligands with turn structure.
@ast
Over one hundred peptide-activ ...... e ligands with turn structure.
@en
prefLabel
Over one hundred peptide-activ ...... e ligands with turn structure.
@ast
Over one hundred peptide-activ ...... e ligands with turn structure.
@en
P356
P1433
P1476
Over one hundred peptide-activ ...... ze ligands with turn structure
@en
P2093
Bernhard Pfeiffer
Giovanni Abbenante
P304
P356
10.1021/CR040689G
P577
2005-03-01T00:00:00Z