The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans
about
Myosin chaperonesSMYD proteins: key regulators in skeletal and cardiac muscle development and functionThe ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositisUCS protein Rng3p is essential for myosin-II motor activity during cytokinesis in fission yeastCardiac-Restricted Expression of VCP/TER94 RNAi or Disease Alleles Perturbs Drosophila Heart Structure and Impairs Function.The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart modelThe Myosin Chaperone UNC-45 Is Organized in Tandem Modules to Support Myofilament Formation in C. elegansUnc45 activates Hsp90-dependent folding of the myosin motor domainUnc45b forms a cytosolic complex with Hsp90 and targets the unfolded myosin motor domainHeat-shock protein 90alpha1 is required for organized myofibril assembly in skeletal muscles of zebrafish embryos.Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy chain during muscle development.Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cellsKnockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos.Recurrent chromosome 16p13.1 duplications are a risk factor for aortic dissections.UNC-45B chaperone: the role of its domains in the interaction with the myosin motor domain.Downregulation of the Hsp90 system causes defects in muscle cells of Caenorhabditis elegansGetting folded: chaperone proteins in muscle development, maintenance and disease.A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells.The UNC-45 myosin chaperone: from worms to flies to vertebrates.Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability.Altered myofilament stoichiometry in response to heart failure in a cardioprotective α-myosin heavy chain transgenic rabbit modelTracking UNC-45 chaperone-myosin interaction with a titin mechanical reporter.UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.A Differentiation Transcription Factor Establishes Muscle-Specific Proteostasis in Caenorhabditis elegans.Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac developmentLoss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells.Shuttling of the chaperones Unc45b and Hsp90a between the A band and the Z line of the myofibrilYeast UCS proteins promote actomyosin interactions and limit myosin turnover in cells.ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degenerationThe myosin-binding UCS domain but not the Hsp90-binding TPR domain of the UNC-45 chaperone is essential for function in Caenorhabditis elegansRationalizing translation attenuation in the network architecture of the unfolded protein response.Smyd1b is required for skeletal and cardiac muscle function in zebrafishBuild it up-Tear it down: protein quality control in the cardiac sarcomere.Another VCP interactor: NF is enoughMutation of the Ser18 phosphorylation site on the sole Saccharomyces cerevisiae UCS protein, She4, can compromise high-temperature survival.Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase.At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis.Rng3, a member of the UCS family of myosin co-chaperones, associates with myosin heavy chains cotranslationally.UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation.
P2860
Q26863588-838F2BC0-0D2D-4209-9C56-30FDD7621AD8Q26865167-DD112507-CF91-460F-9679-C7206F6AF43EQ27301955-AE2B2552-848A-4264-8D50-B90F395282E4Q27302780-FFC858D2-74DD-4322-B55F-F228B3C11305Q27303589-731315EC-A790-4BED-8858-BE3E5BD88F72Q27330328-2FFC5F1D-57E9-4A6C-A27C-DAB3F4F90AD2Q27675937-BBA256CA-A728-473A-A37E-903EA5C77625Q28586476-49867B74-AD88-4590-99E7-FACBDC39B269Q28588643-9D5DD70D-FD07-4D95-999B-BDB46D2E67C5Q30481082-BC6479A4-DB6E-4426-8B0F-5DF1EA9150C6Q33547407-5E66F656-525B-454E-8293-0CDC49A35430Q33619455-D2A5113D-3D48-4E77-8CAD-2F39D7AEF490Q33694916-D132717D-084E-4D62-B3A0-417BF018FF8AQ33940731-39988FAE-5DA8-4C05-B28E-E68125AEC50AQ34031029-512B1361-5810-47DC-A32C-2D24D2D939B5Q34043288-EA7EC4D5-65ED-468E-B930-8EFC82ED0A6EQ34055646-FCA15222-AB34-45D8-ABE2-9F459985268DQ34103449-0E8BAF70-BBF7-4FB2-9966-94D6DB37248CQ34477894-48A9D4CA-BE5F-4CCD-8A9E-ECB4B3D7F579Q34574189-4C75A107-99B5-4472-A171-411AA8485A24Q35071250-984B5DAE-127A-4BFD-8080-617BE59FF1E8Q35926209-0580A756-49FE-48BD-A9A2-5F7D2039551CQ36091809-A518F47D-A8AD-43DA-B734-FB4756EA264CQ36236487-F4653423-199D-4252-AE30-9F9F91B54146Q36289632-6959A46E-52D0-4D48-822E-EE0DEDD16923Q36290852-FED07FB6-4663-408E-9A8D-931190380209Q36344078-2A3E233D-D2F7-4D38-AC0D-803D55E48C2EQ36534622-DD412E8D-2C60-43FC-8914-57FE31645170Q36725660-59D91A3A-9769-49F5-AACC-1BD1776CFD4FQ36758443-F0233DCB-05C6-4838-8CE2-890BC1574954Q36995989-0357720E-DF71-419D-9C9C-72DA730E8199Q37015954-A6D8839F-3216-469B-808E-FD40F7423AE1Q37306191-A558856E-0CF1-47F4-A7B6-B7671F1BA611Q37313697-6A59BF8D-55CD-4A40-A687-13E47154DE43Q39449810-A3BE7389-62D2-47D6-9044-13CB51372F71Q41176499-8098DA45-46B4-45A3-BD6F-874D5E95E347Q41200755-3936CCC8-392E-402A-A4E7-CB12760FBB2BQ41570390-507D4A56-73BC-4217-9966-8F899CEA5F7DQ41839057-9D0BB023-92C2-4C4E-8616-36ECED9A6A18Q42116121-5E9140E5-28D6-4E6B-9C9C-0C590E9DDA7E
P2860
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The UNC-45 chaperone mediates ...... tion in Caenorhabditis elegans
@ast
The UNC-45 chaperone mediates ...... tion in Caenorhabditis elegans
@en
type
label
The UNC-45 chaperone mediates ...... tion in Caenorhabditis elegans
@ast
The UNC-45 chaperone mediates ...... tion in Caenorhabditis elegans
@en
prefLabel
The UNC-45 chaperone mediates ...... tion in Caenorhabditis elegans
@ast
The UNC-45 chaperone mediates ...... tion in Caenorhabditis elegans
@en
P2093
P2860
P356
P1476
The UNC-45 chaperone mediates ...... tion in Caenorhabditis elegans
@en
P2093
Alex H Hutagalung
Henry F Epstein
José M Barral
Megan L Landsverk
P2860
P304
P356
10.1083/JCB.200607084
P407
P577
2007-04-16T00:00:00Z