A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
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The role of titin and extracellular matrix remodelling in heart failure with preserved ejection fractionTitin, a Central Mediator for Hypertrophic Signaling, Exercise-Induced Mechanosignaling and Skeletal Muscle RemodelingScaffold Proteins Regulating Extracellular Regulated Kinase Function in Cardiac Hypertrophy and DiseaseHeart failure with preserved ejection fractionPathophysiological defects and transcriptional profiling in the RBM20-/- rat modelHeart failure with preserved ejection fraction: molecular pathways of the aging myocardiumProbing muscle ankyrin-repeat protein (MARP) structure and functionAcute exercise modifies titin phosphorylation and increases cardiac myofilament stiffnessCardiac titin and heart disease.Protein changes contributing to right ventricular cardiomyocyte diastolic dysfunction in pulmonary arterial hypertensionMechanotransduction in cardiac hypertrophy and failure.Electrical and mechanical stimulation of cardiac cells and tissue constructs.Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle ForceThe multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta (CaMKIIδ) phosphorylates cardiac titin's spring elements.Titin is a major human disease gene.Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction.Tuning the molecular giant titin through phosphorylation: role in health and disease.Key role of ERK1/2 molecular scaffolds in heart pathology.Structure of giant muscle proteins.A rising titan: TTN review and mutation update.New insights in (inter)cellular mechanisms by heart failure with preserved ejection fraction.Titin mutations: the fall of Goliath.Cardiac cytoarchitecture - why the "hardware" is important for heart function!Myocardial reverse remodeling: how far can we rewind?Myofilaments: Movers and Rulers of the Sarcomere.Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes.A change of heart: oxidative stress in governing muscle function?Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn)Two Kinases to Soften the Heart.Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.Hypothesis and theory: mechanical instabilities and non-uniformities in hereditary sarcomere myopathies.When signalling goes wrong: pathogenic variants in structural and signalling proteins causing cardiomyopathies.Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes.Beef tenderness and intramuscular fat proteomic biomarkers: muscle type effect.Splicing Factor RBM20 Regulates Transcriptional Network of Titin Associated and Calcium Handling Genes in The Heart.Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?
P2860
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P2860
A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
A novel mechanism involving fo ...... phosphorylation and mechanics.
@ast
A novel mechanism involving fo ...... phosphorylation and mechanics.
@en
type
label
A novel mechanism involving fo ...... phosphorylation and mechanics.
@ast
A novel mechanism involving fo ...... phosphorylation and mechanics.
@en
prefLabel
A novel mechanism involving fo ...... phosphorylation and mechanics.
@ast
A novel mechanism involving fo ...... phosphorylation and mechanics.
@en
P2093
P2860
P356
P1476
A novel mechanism involving fo ...... phosphorylation and mechanics
@en
P2093
Andrew D McCulloch
Anke Zieseniss
Anna Raskin
Carol C Gregorio
Farah Sheikh
Henk L Granzier
Jeffrey H Omens
Katherine Banares
Katrina G Yamazaki
Leonard K Lee
P2860
P304
29273-29284
P356
10.1074/JBC.M112.372839
P407
P577
2012-07-09T00:00:00Z