Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer - sprookjes - yvandenbroek - TriplyDB

Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer

Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer

http://www.wikidata.org/entity/Q36237514

about

Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma The dual role of tumor lymphatic vessels in dissemination of metastases and immune response development Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment An in vivo method to quantify lymphangiogenesis in zebrafish Network fingerprint: a knowledge-based characterization of biomedical networks.miR-146a enhances the oncogenicity of oral carcinoma by concomitant targeting of the IRAK1, TRAF6 and NUMB genes.The G protein-coupled receptor GALR2 promotes angiogenesis in head and neck cancer.The impact of sphingosine kinase-1 in head and neck cancer.Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations.Sphingosine kinase 1 mediates head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1.A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma.The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.Anti-lymphangiogenic properties of mTOR inhibitors in head and neck squamous cell carcinoma experimental models miR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene.Association between human papilloma virus/Epstein-Barr virus coinfection and oral carcinogenesis.AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic malformation.SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma.Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma Future directions and treatment strategies for head and neck squamous cell carcinomas Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model.Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells.Rab25 regulates invasion and metastasis in head and neck cancer.Clinical application of computed tomography-guided (125)I seed interstitial implantation for head and neck cancer patients with unmanageable cervical lymph node metastases.Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition.PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes.TRAIL induces apoptosis in oral squamous carcinoma cells--a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5.Lymphatic endothelial differentiation in pulmonary lymphangioleiomyomatosis cells.Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers Everolimus exhibits anti-tumorigenic activity in obesity-induced ovarian cancer.Treatment of recurrent metastatic head and neck cancer: focus on cetuximab.mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC.A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis.A multicenter study on expressions of vascular endothelial growth factor, matrix metallopeptidase-9 and tissue inhibitor of metalloproteinase-2 in oral and maxillofacial squamous cell carcinoma.mTOR inhibitors and its role in the treatment of head and neck squamous cell carcinoma.Autophagic action of new targeting agents in head and neck oncology.

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Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer

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0008-5472.CAN-10-3192

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Cancer Research

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Alfredo A Molinolo

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Bhuvanesh Singh

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Cherie-Ann O Nathan

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Christina A Marsh

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Constantinos M Mikelis

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Panomwat Amornphimoltham

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Robert T Dorsam

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Roberto Weigert

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Vyomesh Patel

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P2860

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

Lymphatic endothelium: morphological, molecular and functional properties

Global cancer statistics, 2002

Defining the role of mTOR in cancer

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

Cancer statistics, 2009

Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo.

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis.

The cause of death in patients with head and neck squamous cell carcinoma.

Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.

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7103-7112

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10.1158/0008-5472.CAN-10-3192

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22

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71

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Andrius Masedunskas

J. Silvio Gutkind

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2011-10-05T00:00:00Z

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21975930

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lymphangiogenesis

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3443559

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