Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines
about
Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitroMutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand breakClinical significance of a point mutation in DNA polymerase beta (POLB) gene in gastric cancerInvolvement of DNA polymerase β overexpression in the malignant transformation induced by benzo[a]pyrene.XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes.Does DNA repair occur during somatic hypermutation?DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.Deregulated expression of DNA polymerase β is involved in the progression of genomic instabilityPotential role of meiosis proteins in melanoma chromosomal instabilityInterference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutationThe roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switchOverexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell linesRev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity.Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylaseDNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.Immunomodulation and lymphoma in humans.G648C variant of DNA polymerase β sensitizes esophageal cancer to chemotherapy.The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes.
P2860
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P2860
Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Down-regulation of DNA polymer ...... tation in human BL2 cell lines
@ast
Down-regulation of DNA polymer ...... tation in human BL2 cell lines
@en
type
label
Down-regulation of DNA polymer ...... tation in human BL2 cell lines
@ast
Down-regulation of DNA polymer ...... tation in human BL2 cell lines
@en
prefLabel
Down-regulation of DNA polymer ...... tation in human BL2 cell lines
@ast
Down-regulation of DNA polymer ...... tation in human BL2 cell lines
@en
P2093
P2860
P1433
P1476
Down-regulation of DNA polymer ...... tation in human BL2 cell lines
@en
P2093
Julie K Horton
Rajendra Prasad
Vladimir Poltoratsky
P2860
P304
P356
10.1016/J.DNAREP.2006.10.003
P577
2006-11-28T00:00:00Z