Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.
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Emerging adenosine receptor agonistsMethanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptorsSynthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose ringsRibose modified nucleosides and nucleotides as ligands for purine receptorsStructurally related nucleotides as selective agonists and antagonists at P2Y1 receptorsRing-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modificationsPolyamidoamine (PAMAM) dendrimer conjugate specifically activates the A3 adenosine receptor to improve post-ischemic/reperfusion function in isolated mouse hearts.Predicted structures of agonist and antagonist bound complexes of adenosine A3 receptorFunctionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.Synthesis of a novel conformationally locked carbocyclic nucleoside ring system.John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y ReceptorsAdenosine receptor agonists: from basic medicinal chemistry to clinical development.Partial agonists for A(3) adenosine receptors.Methanocarba ring as a ribose modification in ligands of G protein-coupled purine and pyrimidine receptors: synthetic approaches.Biophysical studies of DNA modified with conformationally constrained nucleotides: comparison of 2'-exo (north) and 3'-exo (south) 'locked' templatesStructure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists.Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors.2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors.Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.Purine receptors: GPCR structure and agonist design(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activityChapter 13. A3 Adenosine Receptors.Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane SubstitutionsDesign of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.Regio- and stereoselective synthesis of truncated 3'-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor.Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system.Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor.Synthesis and pharmacological characterization of [(125)I]MRS1898, a high-affinity, selective radioligand for the rat A(3) adenosine receptor.Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.Crystal structures of the A2A adenosine receptor and their use in medicinal chemistry.Synthesis and Evaluation of 2'-Deoxy-2'-Spirodiflurocyclopropyl Nucleoside Analogs.Selective Phosphorylation of South and North-Cytidine and Adenosine Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases Correlates with Their Growth Inhibitory Effects on Cultured Cells.A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.Synthesis of "reversed" methylenecyclopropane analogues of antiviral phosphonates.Topological sub-structural molecular design (TOPS-MODE): a useful tool to explore key fragments of human A3 adenosine receptor ligands.N6-Substituted 5'-N-Methylcarbamoyl-4'-selenoadenosines as Potent and Selective A3 Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation.
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P2860
Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Methanocarba analogues of puri ...... e adenosine receptor agonists.
@ast
Methanocarba analogues of puri ...... e adenosine receptor agonists.
@en
type
label
Methanocarba analogues of puri ...... e adenosine receptor agonists.
@ast
Methanocarba analogues of puri ...... e adenosine receptor agonists.
@en
prefLabel
Methanocarba analogues of puri ...... e adenosine receptor agonists.
@ast
Methanocarba analogues of puri ...... e adenosine receptor agonists.
@en
P2093
P2860
P356
P1476
Methanocarba analogues of puri ...... ve adenosine receptor agonists
@en
P2093
M A Siddiqui
V E Marquez
P2860
P304
P356
10.1021/JM9905965
P407
P577
2000-06-01T00:00:00Z