Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments
about
Ubiquitylation-dependent localization of PLK1 in mitosisNucleation and Dynamics of Golgi-derived MicrotubulesRegulation of kinetochore-microtubule attachments through homeostatic control during mitosisUsp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis.Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability.Golgi as an MTOC: making microtubules for its own goodChromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways.Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunitDecoding Polo-like kinase 1 signaling along the kinetochore-centromere axisKinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips.A TOGL domain specifically targets yeast CLASP to kinetochores to stabilize kinetochore microtubules.Kinetochore-microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E.Gibbon genome and the fast karyotype evolution of small apes.Genes predict long distance migration and large body size in a migratory fish, Pacific lampreyMio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomesQuantitative phosphoproteomics reveals genistein as a modulator of cell cycle and DNA damage response pathways in triple-negative breast cancer cells.The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores.Increased CDK1 activity determines the timing of kinetochore-microtubule attachments in meiosis I.The Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse OocytesClasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytesMechanisms of Chromosome Congression during Mitosis.Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles.The role of polo-like kinase 1 in carcinogenesis: cause or consequence?Linked in: formation and regulation of microtubule attachments during chromosome segregation.Polo-like kinases: structural variations lead to multiple functions.Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics.Mammalian pre-implantation chromosomal instability: species comparison, evolutionary considerations, and pathological correlations.GSK3-mediated CLASP2 phosphorylation modulates kinetochore dynamics.The CLASP2 Protein Interaction Network in Adipocytes Links CLIP2 to AGAP3, CLASP2 to G2L1, MARK2, and SOGA1, and Identifies SOGA1 as a Microtubule-Associated Protein.The equilibrium of ubiquitination and deubiquitination at PLK1 regulates sister chromatid separation.Phosphorylation of Serine 148 in Giardia lamblia End-binding 1 Protein is Important for Cell Division.Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies.Phosphorylation of Astrin Regulates Its Kinetochore Function.Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis.Plk1 is essential for proper chromosome segregation during meiosis I/meiosis II transition in pig oocytes.Centrosome nucleates numerous ephemeral microtubules and only few of them participate in the radial array.Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.Regulators of Spindle Microtubules and Their Mechanisms: Living Together Matters.Polo-like kinase 1 inhibition results in misaligned chromosomes and aberrant spindles in porcine oocytes during the first meiotic division.Plk1 inhibition leads to a failure of mitotic division during the first mitotic division in pig embryos.
P2860
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P2860
Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
Cdk1 and Plk1 mediate a CLASP2 ...... ochore-microtubule attachments
@ast
Cdk1 and Plk1 mediate a CLASP2 ...... ochore-microtubule attachments
@en
type
label
Cdk1 and Plk1 mediate a CLASP2 ...... ochore-microtubule attachments
@ast
Cdk1 and Plk1 mediate a CLASP2 ...... ochore-microtubule attachments
@en
prefLabel
Cdk1 and Plk1 mediate a CLASP2 ...... ochore-microtubule attachments
@ast
Cdk1 and Plk1 mediate a CLASP2 ...... ochore-microtubule attachments
@en
P2093
P2860
P50
P356
P1476
Cdk1 and Plk1 mediate a CLASP2 ...... ochore-microtubule attachments
@en
P2093
Ana R R Maia
Irina Kaverina
Lilian Kabeche
Stefano Maffini
P2860
P304
P356
10.1083/JCB.201203091
P407
P577
2012-10-08T00:00:00Z