PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity - sprookjes - yvandenbroek - TriplyDB

PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity

PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity

http://www.wikidata.org/entity/Q36317718

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Pharmacogenomics in Pediatric Oncology: Review of Gene-Drug Associations for Clinical Use Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies.Genes implicated in thiopurine-induced toxicity: Comparing TPMT enzyme activity with clinical phenotype and exome data in a paediatric IBD cohort.The Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance Treatment.Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes.Association of ITPA genotype with event-free survival and relapse rates in children with acute lymphoblastic leukemia undergoing maintenance therapy PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy.TPMT genetic variants are associated with increased rejection with azathioprine use in heart transplantation.Multilocus genotypes of relevance for drug metabolizing enzymes and therapy with thiopurines in patients with acute lymphoblastic leukemia.Pharmacogenetic considerations for acute lymphoblastic leukemia therapies.Pharmacogenetics of childhood acute lymphoblastic leukemia.Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia.Update on thiopurine pharmacogenetics in inflammatory bowel disease.Pharmacogenetic Predictors of Treatment-Related Toxicity Among Children With Acute Lymphoblastic Leukemia.Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine.Pharmacogenetics and induction/consolidation therapy toxicities in acute lymphoblastic leukemia patients treated with AIEOP-BFM ALL 2000 protocol.NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD.Tip-to-tip interaction in the crystal packing of PACSIN 2 is important in regulating tubulation activity.From pharmacogenetics to pharmacometabolomics: SAM modulates TPMT activity.Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait.Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity.Revisiting the Role of Thiopurines in Inflammatory Bowel Disease Through Pharmacogenomics and Use of Novel Methods for Therapeutic Drug Monitoring

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PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity

http://www.wikidata.org/entity/Q36317718

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2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

PACSIN2 polymorphism influence ...... ated gastrointestinal toxicity

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PACSIN2 polymorphism influence ...... ated gastrointestinal toxicity

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PACSIN2 polymorphism influence ...... ated gastrointestinal toxicity

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PACSIN2 polymorphism influence ...... ated gastrointestinal toxicity

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PACSIN2 polymorphism influence ...... ated gastrointestinal toxicity

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PACSIN2 polymorphism influence ...... ated gastrointestinal toxicity

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Human Molecular Genetics

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PACSIN2 polymorphism influence ...... ated gastrointestinal toxicity

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Barthelemy Diouf

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Cheng Cheng

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Deqing Pei

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Joseph Robert McCorkle

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Kristine R Crews

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Marco Rabusin

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Margherita Londero

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Maria Grazia Valsecchi

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Mary V Relling

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Raffaella Franca

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P2860

Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

Network organization of the human autophagy system

Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin

PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b

ENCODE whole-genome data in the UCSC genome browser (2011 update)

Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci

Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing

Treating childhood acute lymphoblastic leukemia without cranial irradiation

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10.1093/HMG/DDS302

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21

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21

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Gabriele Stocco

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2012-07-30T00:00:00Z

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