Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection.
about
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cellsLKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selectionQuantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Regulation of T cell development and activation by creatine kinase B.Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes.The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus.Overlapping and asymmetric functions of TCR signaling during thymic selection of CD4 and CD8 lineagesLineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiationDecision checkpoints in the thymus.The enigma of CD4-lineage specification.The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells.Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice.Gads-deficient thymocytes are blocked at the transitional single positive CD4+ stage.Theories and quantification of thymic selection.A Zap70-dependent feedback circuit is essential for efficient selection of CD4 lineage thymocytes.The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression.Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus.The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity.Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.Regulation of Tcrb recombination ordering by c-Fos-dependent RAG deposition.Engineering a Dual Small Molecule Gated ZAP70 Switch in T Cells.A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.
P2860
Q28585402-EDAC0356-1934-4128-A106-53F937BE5E34Q28589094-40969A48-08E2-4C2F-A6C4-FC9B56F5CAF0Q30583549-804BC261-4167-4FCE-8FA7-0B6A736E5972Q33425184-B6E06336-41DC-4A09-B6C4-C15F20258F92Q33567980-0806BB43-FBB8-4FA2-8F24-E71A83884276Q33591069-BCEC6EDD-3E82-4AFD-A4E8-128AF727C9F8Q33638200-88A332F6-F9EE-45CD-B44E-65BEDEA0FDBFQ34831201-DAA45329-8EDB-433E-A13A-F58350117956Q36014992-85690F18-F728-41EC-BA4B-E60030585B8DQ36059447-68C578D0-31C3-49CB-AD7C-614ECAA38B03Q36073436-B4E84D22-FEE1-4421-ADCF-97F3ACC627AFQ36073462-31BF5C6A-F4E3-48DE-BAD0-B03FD912B4A1Q36085339-D2354AC2-725C-4CBF-8C97-D9F8CFE72A08Q36403942-A6017E35-851F-4ADD-8DD4-990C507C9547Q37400400-8804AF3B-9C4E-432B-A6EF-DFC96FB9E869Q37551442-6FAE9975-CC4D-41DB-941C-3571C84ECAB1Q41533951-E3D8A6F1-9437-4872-B780-23760375161CQ43211202-4990CF2E-FADA-4610-B433-2A5E58E8205EQ44346356-B16797EA-B436-4B81-9C4E-4B9CDEC7AFB1Q45065835-42514C54-64D3-433E-AC6E-5E62C61A436EQ52093756-E91FDE32-5803-4D40-9088-F73ABC4E9482Q52587084-01507FAE-2325-46E9-83BC-5A14F2B82CD8Q52625841-32E43E42-FF51-4F16-BF13-2E3271B66F52Q54394899-D82CB844-AB0F-4B5E-A99E-4C79AAF5CC16
P2860
Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Restricting Zap70 expression t ...... pletion of positive selection.
@ast
Restricting Zap70 expression t ...... pletion of positive selection.
@en
type
label
Restricting Zap70 expression t ...... pletion of positive selection.
@ast
Restricting Zap70 expression t ...... pletion of positive selection.
@en
prefLabel
Restricting Zap70 expression t ...... pletion of positive selection.
@ast
Restricting Zap70 expression t ...... pletion of positive selection.
@en
P2093
P2860
P356
P1476
Restricting Zap70 expression t ...... pletion of positive selection.
@en
P2093
Anthony Adams
Kathryn F Wildt
Lionel Feigenbaum
Rémy Bosselut
Xiaolong Liu
P2860
P304
P356
10.1084/JEM.20021698
P407
P577
2003-02-01T00:00:00Z