DNA-dependent protein kinase activity is not required for immunoglobulin class switching. - sprookjes - yvandenbroek - TriplyDB

DNA-dependent protein kinase activity is not required for immunoglobulin class switching.

DNA-dependent protein kinase activity is not required for immunoglobulin class switching.

http://www.wikidata.org/entity/Q36371923

about

Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions Mlh1 can function in antibody class switch recombination independently of Msh2 Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination.Mechanism and regulation of class switch recombination De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Class-switch recombination: after the dawn of AID.The role of DNA breaks in genomic instability and tumorigenesis.The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination The role of the non-homologous end-joining pathway in lymphocyte development.Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects.Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.AID to overcome the limitations of genomic information.Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation ATM is required for efficient recombination between immunoglobulin switch regions.Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factor Fixing DNA breaks during class switch recombination.DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining.Non-homologous end joining in class switch recombination: the beginning of the end Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency.Altered kinetics of nonhomologous end joining and class switch recombination in ligase IV-deficient B cells.NHEJ-deficient DT40 cells have increased levels of immunoglobulin gene conversion: evidence for a double strand break intermediate.Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops.Paradigm switching in the germinal center.

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P2860

DNA-dependent protein kinase activity is not required for immunoglobulin class switching.

http://www.wikidata.org/entity/Q36371923

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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2002年學術文章

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name

DNA-dependent protein kinase activity is not required for immunoglobulin class switching.

@ast

DNA-dependent protein kinase activity is not required for immunoglobulin class switching.

@en

type

label

DNA-dependent protein kinase activity is not required for immunoglobulin class switching.

@ast

DNA-dependent protein kinase activity is not required for immunoglobulin class switching.

@en

prefLabel

DNA-dependent protein kinase activity is not required for immunoglobulin class switching.

@ast

DNA-dependent protein kinase activity is not required for immunoglobulin class switching.

@en

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P1433

Journal of Experimental Medicine

P1476

DNA-dependent protein kinase activity is not required for immunoglobulin class switching.

@en

P2093

Donna M Fath

http://www.w3.org/2001/XMLSchema#string

Gayle C Bosma

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Jiyoon Kim

http://www.w3.org/2001/XMLSchema#string

Maria G Cotticelli

http://www.w3.org/2001/XMLSchema#string

Marko Z Radic

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Melvin J Bosma

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Norman R Ruetsch

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Teresa Urich

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P2860

Synapsis of DNA ends by DNA-dependent protein kinase

A DNA-activated protein kinase from HeLa cell nuclei

B cell differentiation and isotype switching is related to division cycle number

DNA double-strand breaks: signaling, repair and the cancer connection

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

P304

1483-1495

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scholarly article

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10.1084/JEM.20001871

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11

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196

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2002-12-01T00:00:00Z

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11009710

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12461083

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2194268

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