Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy
about
Putting a bit into the polo-box domain of polo-like kinase 1Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assayCurrent progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents.Inhibitors of the Polo-Box Domain of Polo-Like Kinase 1.Selective blockade of cancer cell proliferation and anchorage-independent growth by Plk1 activity-dependent suicidal inhibition of its polo-box domainKinase inhibitors as potential agents in the treatment of multiple myeloma.SWIM: a computational tool to unveiling crucial nodes in complex biological networks.Regulation of PLK1 through competition between hnRNPK, miR-149-3p and miR-193b-5p.Phosphatase-Stable Phosphoamino Acid Mimetics That Enhance Binding Affinities with the Polo-Box Domain of Polo-like Kinase 1.The phosphorylation-dependent regulation of nuclear SREBP1 during mitosis links lipid metabolism and cell growth.Application of oxime-diversification to optimize ligand interactions within a cryptic pocket of the polo-like kinase 1 polo-box domain.Polo-like kinase 1 (Plk1) overexpression enhances ionizing radiation-induced cancer formation in mice.The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis.Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer.The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation.Linear Regression QSAR Models for Polo-Like Kinase-1 Inhibitors.Several inhibitors of the Plk1 Polo-Box Domain turn out to be non-specific protein alkylators.Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.Enhancing polo-like kinase 1 selectivity of polo-box domain-binding peptides.
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Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy
description
2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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2015年学术文章
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2015年学术文章
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2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
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2015年學術文章
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2015年學術文章
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name
Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy
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Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy
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type
label
Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy
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Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy
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prefLabel
Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy
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Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy
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P2093
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Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy
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Eunhye Lee
Jeong K Bang
Jung-Eun Park
Kyung S Lee
Terrence R Burke
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P304
P356
10.1016/J.TIPS.2015.08.013
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2015-10-14T00:00:00Z