Stromal platelet-derived growth factor receptor α (PDGFRα) provides a therapeutic target independent of tumor cell PDGFRα expression in lung cancer xenografts.
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Use of rodents as models of human diseasesPDGFRα in liver pathophysiology: emerging roles in development, regeneration, fibrosis, and cancerTargeting the PDGF signaling pathway in tumor treatmentA phase I dose-escalation study of MEDI-575, a PDGFRα monoclonal antibody, in adults with advanced solid tumorsOlaratumab: First Global Approval.Vitamin D Analogs Potentiate the Antitumor Effect of Imatinib Mesylate in a Human A549 Lung Tumor Model.Role and regulation of PDGFRα signaling in liver development and regenerationBIBF 1120 (nintedanib), a triple angiokinase inhibitor, induces hypoxia but not EMT and blocks progression of preclinical models of lung and pancreatic cancer.Therapeutic targeting of platelet-derived growth factor receptors in solid tumors.Investigational therapies up to Phase II which target PDGF receptors: potential anti-cancer therapeutics.Variability in Platelet-Derived Growth Factor Receptor Alpha Antibody Specificity May Impact Clinical Utility of Immunohistochemistry Assays.Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivoPDGFR-modulated miR-23b cluster and miR-125a-5p suppress lung tumorigenesis by targeting multiple components of KRAS and NF-kB pathways.Olaratumab: a platelet-derived growth factor receptor-α-blocking antibody for the treatment of soft tissue sarcoma.Phase II study of olaratumab with paclitaxel/carboplatin (P/C) or P/C alone in previously untreated advanced NSCLC.A phase I study of olaratumab, an anti-platelet-derived growth factor receptor alpha (PDGFRα) monoclonal antibody, in patients with advanced solid tumors.
P2860
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P2860
Stromal platelet-derived growth factor receptor α (PDGFRα) provides a therapeutic target independent of tumor cell PDGFRα expression in lung cancer xenografts.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
Stromal platelet-derived growt ...... ion in lung cancer xenografts.
@ast
Stromal platelet-derived growt ...... ion in lung cancer xenografts.
@en
type
label
Stromal platelet-derived growt ...... ion in lung cancer xenografts.
@ast
Stromal platelet-derived growt ...... ion in lung cancer xenografts.
@en
prefLabel
Stromal platelet-derived growt ...... ion in lung cancer xenografts.
@ast
Stromal platelet-derived growt ...... ion in lung cancer xenografts.
@en
P2093
P2860
P1476
Stromal platelet-derived growt ...... ion in lung cancer xenografts.
@en
P2093
Colleen Burns
David E Gerber
Inga Duignan
Jason E Toombs
Jennifer Malaby
Michael Peyton
Michael T Dellinger
Nick Loizos
Puja Gupta
Rolf A Brekken
P2860
P304
P356
10.1158/1535-7163.MCT-12-0431
P577
2012-08-28T00:00:00Z