DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination. - sprookjes - yvandenbroek - TriplyDB

DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

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Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination Etoposide induces nuclear re-localisation of AID Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η.Correlation of phenotype/genotype in a cohort of 23 xeroderma pigmentosum-variant patients reveals 12 new disease-causing POLH mutations DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification An overview of Y-Family DNA polymerases and a case study of human DNA polymerase η A regulatory role for NBS1 in strand-specific mutagenesis during somatic hypermutation Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells.Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.AID and somatic hypermutation.Controlling somatic hypermutation in immunoglobulin variable and switch regions.Modeling DNA polymerase μ motions: subtle transitions before chemistry.DNA polymerases and somatic hypermutation of immunoglobulin genes MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair.DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.Mechanism and regulation of class switch recombination AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.DNA deamination in immunity.Does DNA repair occur during somatic hypermutation?DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination Antibody diversification caused by disrupted mismatch repair and promiscuous DNA polymerases Regulation of AID, the B-cell genome mutator.Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.Low-fidelity DNA synthesis by human DNA polymerase theta.Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression.Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes.Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.Hijacked DNA repair proteins and unchained DNA polymerases.

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P2860

DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

http://www.wikidata.org/entity/Q36399002

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2004 nî lūn-bûn

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2004年の論文

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DNA polymerase eta is involved ...... in class switch recombination.

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DNA polymerase eta is involved ...... in class switch recombination.

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DNA polymerase eta is involved ...... in class switch recombination.

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DNA polymerase eta is involved ...... in class switch recombination.

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DNA polymerase eta is involved ...... lin class switch recombination

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Ahmad Faili

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Alain Sarasin

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Anne Stary

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Claude-Agnès Reynaud

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Françoise Vuillier

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Jean-Claude Weill

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P2860

Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

Chronic lymphocytic leukemia B cells expressing AID display dissociation between class switch recombination and somatic hypermutation

The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant

The Smu tandem repeat region is critical for Ig isotype switching in the absence of Msh2

129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation

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2

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8909685

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14734526

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2211761

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