The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO - sprookjes - yvandenbroek - TriplyDB

The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO

The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO

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Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions-A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of Cardiology Nitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic Properties A tale of two gases: NO and H2S, foes or friends for life?Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application Acidity and hydrogen exchange dynamics of iron(II)-bound nitroxyl in aqueous solution.Molecular regulation of tumor angiogenesis and perfusion via redox signaling.Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway.Reactions of HNO with heme proteins: new routes to HNO-heme complexes and insight into physiological effects.Proton-induced reactivity of NO⁻ from a {CoNO}⁸ complex Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class.Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation properties Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674.The chemistry of nitroxyl-releasing compounds.New acyloxy nitroso compounds with improved water solubility and nitroxyl (HNO) release kinetics and inhibitors of platelet aggregation Design and Synthesis of Near-infrared Fluorescent Probes for Imaging of Biological Nitroxyl.Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function.Biological signaling by small inorganic molecules Pharmacological characterization of 1-nitrosocyclohexyl acetate, a long-acting nitroxyl donor that shows vasorelaxant and antiaggregatory effects.Xerogel optical sensor films for quantitative detection of nitroxyl The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats.Recent advances in the chemical biology of nitroxyl (HNO) detection and generation.Identification of nitroxyl-induced modifications in human platelet proteins using a novel mass spectrometric detection method.The effects of nitroxyl (HNO) on H₂O₂ metabolism and possible mechanisms of HNO signaling.The emergence of nitroxyl (HNO) as a pharmacological agent.Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.Cardioprotection by metabolic shut-down and gradual wake-up.Hydroxamic acids (therapeutics and mechanism): chemistry, acyl nitroso, nitroxyl, reactive oxygen species, and cell signaling.Cardiac inotropes: current agents and future directions.Nitroxyl (HNO) for treatment of acute heart failure.Recent developments in chimeric NSAIDs as safer anti-inflammatory agents.Discriminative EPR detection of NO and HNO by encapsulated nitronyl nitroxides.A Phase 2a dose-escalation study of the safety, tolerability, pharmacokinetics and haemodynamic effects of BMS-986231 in hospitalized patients with heart failure with reduced ejection fraction.Therapeutic Potential of Nitroxyl (HNO) Donors in the Management of Acute Decompensated Heart Failure.Caffeine inhibition of GLUT1 is dependent on the activation state of the transporter.Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe.Hydroxylamine acutely activates glucose uptake in L929 fibroblast cells.Nitroxyl (HNO) acutely activates the glucose uptake activity of GLUT1.Nitroxyl as a ligand in ruthenium tetraammine systems: a density functional theory study.Nitroxyl accelerates the oxidation of oxyhemoglobin by nitrite

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The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO

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J.PHARMTHERA.2006.11.002

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Pharmacology & Therapeutics

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The pharmacology of nitroxyl ( ...... not just the Janus face of NO

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Brenda E Lopez

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David A Wink

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Jon M Fukuto

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Katrina Miranda

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Matthew I Jackson

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Reduction of S-nitrosoglutathione by human alcohol dehydrogenase 3 is an irreversible reaction as analysed by electrospray mass spectrometry

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

Role of nitric oxide in cardiovascular adaptation to intermittent hypoxia

Formation of nitric oxide from nitroxyl anion: role of quinones and ferricytochrome c

Vascular smooth muscle relaxation mediated by nitric oxide donors: a comparison with acetylcholine, nitric oxide and nitroxyl ion

The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

Hydrolysis of Acyloxy Nitroso Compounds Yields Nitroxyl (HNO)

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide

Spin-forbidden deprotonation of aqueous nitroxyl (HNO).

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10.1016/J.PHARMTHERA.2006.11.002

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Nazareno Paolocci

Carlo Gabriele Tocchetti

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