Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.
about
CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2.Class IIa HDACs - new insights into their functions in physiology and pathology.The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphoma.The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases.Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes.Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells.
P2860
Q35136778-E11BA244-86D0-4D34-9B92-4AE2218FB6CBQ38253128-A6D4A441-ECA3-463B-9207-B159791771FEQ38910415-4F0B8E7B-A2FE-49B1-BD99-0151B89B7C6FQ39197659-464BD883-648D-4491-9518-B144BD3A7387Q40188158-65A8E24B-82F3-45E5-AA22-538DFE8561F5Q42709956-F0F9EE42-0871-40EF-A533-23CDF6C133B3Q54943540-81B494BB-6FFE-44A8-972A-4EF255A71782
P2860
Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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name
Nuclear export of histone deac ...... red for immune self-tolerance.
@ast
Nuclear export of histone deac ...... red for immune self-tolerance.
@en
type
label
Nuclear export of histone deac ...... red for immune self-tolerance.
@ast
Nuclear export of histone deac ...... red for immune self-tolerance.
@en
prefLabel
Nuclear export of histone deac ...... red for immune self-tolerance.
@ast
Nuclear export of histone deac ...... red for immune self-tolerance.
@en
P2093
P2860
P356
P1433
P1476
Nuclear export of histone deac ...... ired for immune self-tolerance
@en
P2093
Amy M Collins
Denis Mottet
Herbert G Kasler
Hyung W Lim
Intelly S Lee
P2860
P304
P356
10.1038/EMBOJ.2012.295
P407
P50
P577
2012-10-26T00:00:00Z