PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer
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Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the SpotRecent Advances in Understanding Amino Acid Sensing Mechanisms that Regulate mTORC1The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling.K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycleNutrient sensing and TOR signaling in yeast and mammals.A systems study reveals concurrent activation of AMPK and mTOR by amino acids.mTORC1 as the main gateway to autophagy.p-ULK1 phosphorylates DENND3DENND3 exchanges GTP for GDP on RAB12Royal Society Scientific Meeting: Extracellular vesicles in the tumour microenvironment.PATs and SNATs: Amino Acid Sensors in Disguise.
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P2860
PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer
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2015 nî lūn-bûn
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2015年の論文
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2015年学术文章
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name
PAT4 levels control amino-acid ...... l outcome in colorectal cancer
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PAT4 levels control amino-acid ...... l outcome in colorectal cancer
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type
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PAT4 levels control amino-acid ...... l outcome in colorectal cancer
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PAT4 levels control amino-acid ...... l outcome in colorectal cancer
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PAT4 levels control amino-acid ...... l outcome in colorectal cancer
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PAT4 levels control amino-acid ...... l outcome in colorectal cancer
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P2093
P2860
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PAT4 levels control amino-acid ...... l outcome in colorectal cancer
@en
P2093
A L Harris
D C I Goberdhan
R McCormick
S Heublein
S M W Perera
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P2888
P304
P356
10.1038/ONC.2015.363
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2015-10-05T00:00:00Z