Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells - sprookjes - yvandenbroek - TriplyDB

Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells

Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells

http://www.wikidata.org/entity/Q36455890

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NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin.SLK/LOSK kinase regulates cell motility independently of microtubule organization and Golgi polarization Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome Cordon Bleu serves as a platform at the basal region of microvilli, where it regulates microvillar length through its WH2 domains.Ezrin activation by LOK phosphorylation involves a PIP2-dependent wedge mechanism.Regulation of Ste20-like kinase, SLK, activity: Dimerization and activation segment phosphorylation.Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells.SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation ERM proteins at a glance Shaping the intestinal brush border CLIC5 stabilizes membrane-actin filament linkages at the base of hair cell stereocilia in a molecular complex with radixin, taperin, and myosin VI.The function and dynamics of the apical scaffolding protein E3KARP are regulated by cell-cycle phosphorylation.Caspase Cleavages of the Lymphocyte-oriented Kinase Prevent Ezrin, Radixin, and Moesin Phosphorylation during Apoptosis.Conditional knockout of polarity complex (atypical) PKCι reveals an anti-inflammatory function mediated by NF-κB.The tails of apical scaffolding proteins EBP50 and E3KARP regulate their localization and dynamics.Interactome analysis reveals ezrin can adopt multiple conformational states.Organization and execution of the epithelial polarity programme.Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells.Plasticity of the brush border - the yin and yang of intestinal homeostasis.Akt2-Dependent Phosphorylation of Radixin in Regulation of Mrp-2 Trafficking in WIF-B Cells.Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation.Regulation of Catalytic and Non-catalytic Functions of the Drosophila Ste20 Kinase Slik by Activation Segment Phosphorylation Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation.A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.An apical MRCK-driven morphogenetic pathway controls epithelial polarity.Intestinal epithelial cell polarity defects in disease: lessons from microvillus inclusion disease.Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

P2860

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P2860

Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells

http://www.wikidata.org/entity/Q36455890

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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name

Local phosphocycling mediated ...... cal aspect of epithelial cells

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Local phosphocycling mediated ...... cal aspect of epithelial cells

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Local phosphocycling mediated ...... cal aspect of epithelial cells

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Journal of Cell Biology

P1476

Local phosphocycling mediated ...... cal aspect of epithelial cells

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P2093

Anthony Bretscher

http://www.w3.org/2001/XMLSchema#string

Marcus B Smolka

http://www.w3.org/2001/XMLSchema#string

Patrice Y Ohouo

http://www.w3.org/2001/XMLSchema#string

Raghuvir Viswanatha

http://www.w3.org/2001/XMLSchema#string

P2860

Rap2A links intestinal cell polarity to brush border formation

The scaffolding protein EBP50 regulates microvillar assembly in a phosphorylation-dependent manner

Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress

The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain

LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation

Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway

Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

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969-984

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scholarly article

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10.1083/JCB.201207047

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6

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199

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2012-12-03T00:00:00Z

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233840423

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23209304

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3518218

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