Small-angle X-ray scattering and single-molecule FRET spectroscopy produce highly divergent views of the low-denaturant unfolded state.
about
SAXS studies of RNA: structures, dynamics, and interactions with partnersComparing protein folding in vitro and in vivo: foldability meets the fitness challengeA comparison of the folding kinetics of a small, artificially selected DNA aptamer with those of equivalently simple naturally occurring proteins.Microsecond barrier-limited chain collapse observed by time-resolved FRET and SAXS.Modulation of frustration in folding by sequence permutation.Modest influence of FRET chromophores on the properties of unfolded proteins.Quantitative assessments of the distinct contributions of polypeptide backbone amides versus side chain groups to chain expansion via chemical denaturationBenchmarking all-atom simulations using hydrogen exchange.Synergy in protein-osmolyte mixtures.Random coil negative control reproduces the discrepancy between scattering and FRET measurements of denatured protein dimensions.Förster resonance energy transfer: Role of diffusion of fluorophore orientation and separation in observed shifts of FRET efficiency.Cooperative folding near the downhill limit determined with amino acid resolution by hydrogen exchangeComprehensive structural and dynamical view of an unfolded protein from the combination of single-molecule FRET, NMR, and SAXS.Minimal effects of macromolecular crowding on an intrinsically disordered protein: a small-angle neutron scattering study.Shedding light on protein folding landscapes by single-molecule fluorescence.Consistent View of Polypeptide Chain Expansion in Chemical Denaturants from Multiple Experimental Methods.Dimension conversion and scaling of disordered protein chains.Probing the Action of Chemical Denaturant on an Intrinsically Disordered Protein by Simulation and Experiment.Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurementsContext and force field dependence of the loss of protein backbone entropy upon folding using realistic denatured and native state ensemblesProtein unfolding mechanisms and their effects on folding experiments.An in vitro tag-and-modify protein sample generation method for single-molecule fluorescence resonance energy transfer.Exploring the Denatured State Ensemble by Single-Molecule Chemo-Mechanical Unfolding: The Effect of Force, Temperature, and Urea.Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water.Conformational Heterogeneity and FRET Data Interpretation for Dimensions of Unfolded Proteins.SAXS versus FRET: A Matter of Heterogeneity?Simultaneous Determination of Two Subdomain Folding Rates Using the "Transfer-Quench" Method.Protein collapse is encoded in the folded state architecture.Hypothesis: structural heterogeneity of the unfolded proteins originating from the coupling of the local clusters and the long-range distance distribution.Sequence- and Temperature-Dependent Properties of Unfolded and Disordered Proteins from Atomistic Simulations.Simplified protein models: predicting folding pathways and structure using amino acid sequences.
P2860
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P2860
Small-angle X-ray scattering and single-molecule FRET spectroscopy produce highly divergent views of the low-denaturant unfolded state.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-my
2012年学术文章
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2012年學術文章
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name
Small-angle X-ray scattering a ...... low-denaturant unfolded state.
@ast
Small-angle X-ray scattering a ...... low-denaturant unfolded state.
@en
type
label
Small-angle X-ray scattering a ...... low-denaturant unfolded state.
@ast
Small-angle X-ray scattering a ...... low-denaturant unfolded state.
@en
prefLabel
Small-angle X-ray scattering a ...... low-denaturant unfolded state.
@ast
Small-angle X-ray scattering a ...... low-denaturant unfolded state.
@en
P2093
P2860
P1476
Small-angle X-ray scattering a ...... low-denaturant unfolded state.
@en
P2093
Gilad Haran
James Hinshaw
Kevin Plaxco
Lois Pollack
Steve P Meisburger
Tae Yeon Yoo
P2860
P304
P356
10.1016/J.JMB.2012.01.016
P407
P577
2012-01-27T00:00:00Z