Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.
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The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sexWorking to Eliminate Cancer Health Disparities from Tobacco: A Review of the National Cancer Institute's Community Networks Program.High CYP2A6 enzyme activity as measured by a caffeine test and unique distribution of CYP2A6 variant alleles in Ethiopian population.Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokersKnown and novel sources of variability in the nicotine metabolite ratio in a large sample of treatment-seeking smokersCYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers--findings from two independent populationsVariation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake.Nicotine metabolite ratio (3-hydroxycotinine/cotinine) in plasma and urine by different analytical methods and laboratories: implications for clinical implementation.Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2.CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users.Health effects associated with measured levels of contaminants in the Arctic.Novel CYP2A6 variants identified in African Americans are associated with slow nicotine metabolism in vitro and in vivo.Nicotine Metabolite Ratio Is Associated With Lozenge Use But Not Quitting in Smokeless Tobacco Users.Perceptions of pharmacogenetic research to guide tobacco cessation by patients, providers and leaders in a tribal healthcare setting.Does ethnic ancestry play a role in smoking?Variation in CYP2A6 Activity and Personalized Medicine.Relationships between smoking behaviors and cotinine levels among two American Indian populations with distinct smoking patterns.Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer.Biomarkers of tobacco smoke exposure in racial/ethnic groups at high risk for lung cancer.A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s.
P2860
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P2860
Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Alaska Native smokers and smok ...... fic nitrosamine bioactivation.
@ast
Alaska Native smokers and smok ...... fic nitrosamine bioactivation.
@en
type
label
Alaska Native smokers and smok ...... fic nitrosamine bioactivation.
@ast
Alaska Native smokers and smok ...... fic nitrosamine bioactivation.
@en
prefLabel
Alaska Native smokers and smok ...... fic nitrosamine bioactivation.
@ast
Alaska Native smokers and smok ...... fic nitrosamine bioactivation.
@en
P2093
P2860
P356
P1433
P1476
Alaska Native smokers and smok ...... fic nitrosamine bioactivation.
@en
P2093
Andy Z X Zhu
Caroline C Renner
Clifford H Watson
Connie S Sosnoff
Dorothy K Hatsukami
Irina Stepanov
Matthew J Binnington
Neal L Benowitz
Rachel F Tyndale
P2860
P304
P356
10.1093/CARCIN/BGS306
P407
P577
2012-10-01T00:00:00Z