Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB).
about
Targeting TRPM2 in ROS-Coupled DiseasesThe TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermiaActivation of store-operated I(CRAC) by hydrogen peroxide.Pathophysiologically relevant levels of hydrogen peroxide induce glutamate-independent neurodegeneration that involves activation of transient receptor potential melastatin 7 channelsTransient receptor potential (TRP) channels: a clinical perspectiveFlufenamic acid as an ion channel modulator.Regulation of Ca2+ signaling with particular focus on mast cells.Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 channels.Regulation of Substantia Nigra Pars Reticulata GABAergic Neuron Activity by H₂O₂ via Flufenamic Acid-Sensitive Channels and K(ATP) ChannelsThe key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction.H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the beta-cells: involvement of TRPM2 channels.Tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells depends on Ca2+ influx through plasma membrane Ca2+ channelsPotent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs.Inhibition of the transient receptor potential melastatin-2 channel causes increased DNA damage and decreased proliferation in breast adenocarcinoma cellsSex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke.Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions.2-aminoethyl diphenyl borinate (2-APB) inhibits TRPM7 channels through an intracellular acidification mechanism.Enhanced cytotoxicity in triple-negative and estrogen receptor‑positive breast adenocarcinoma cells due to inhibition of the transient receptor potential melastatin-2 channel.Francisella tularensis Catalase Restricts Immune Function by Impairing TRPM2 Channel Activity.The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury.Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.Endothelin-1-induced vasoconstriction does not require intracellular Ca²⁺ waves in arteries from rats exposed to intermittent hypoxia.Pharmacology of transient receptor potential melastatin channels in the vasculatureVanilloid and melastatin transient receptor potential channels in vascular smooth muscleTRPM2 channel properties, functions and therapeutic potentials.TRPM2: a multifunctional ion channel for calcium signalling.TRPM2 cation channels, oxidative stress and neurological diseases: where are we now?Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1.Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling.TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death.Above and beyond C5a Receptor Targeting by Staphylococcal Leucotoxins: Retrograde Transport of Panton-Valentine Leucocidin and γ-Hemolysin.Selenium modulates oxidative stress-induced TRPM2 cation channel currents in transfected Chinese hamster ovary cells.The TRPM2 channel: A thermo-sensitive metabolic sensor.DIDS (4,4'-Diisothiocyanatostilbene-2,2'-disulfonate) directly inhibits caspase activity in HeLa cell lysates.Shear stress activates monovalent cation channel transient receptor potential melastatin subfamily 4 in rat atrial myocytes via type 2 inositol 1,4,5-trisphosphate receptors and Ca(2+) release.Characterization of constitutive and acid-induced outwardly rectifying chloride currents in immortalized mouse distal tubular cellsModulation of activation and inactivation by Ca2+ and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis.Advanced glycation end products (AGEs) activate mast cells.Cyclic ADP ribose is a novel regulator of intracellular Ca2+ oscillations in human bone marrow mesenchymal stem cells.TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1.
P2860
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P2860
Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB).
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Inhibition of the transient re ...... ethoxydiphenyl borate (2-APB).
@ast
Inhibition of the transient re ...... ethoxydiphenyl borate (2-APB).
@en
type
label
Inhibition of the transient re ...... ethoxydiphenyl borate (2-APB).
@ast
Inhibition of the transient re ...... ethoxydiphenyl borate (2-APB).
@en
prefLabel
Inhibition of the transient re ...... ethoxydiphenyl borate (2-APB).
@ast
Inhibition of the transient re ...... ethoxydiphenyl borate (2-APB).
@en
P2860
P356
P1476
Inhibition of the transient re ...... oethoxydiphenyl borate (2-APB)
@en
P2093
P2860
P304
P356
10.1038/SJ.BJP.0707675
P407
P577
2008-01-21T00:00:00Z