Aiolos promotes TH17 differentiation by directly silencing Il2 expression
about
Recent advances in understanding the molecular mechanisms of the development and function of Th17 cellsTh17 plasticity and its changes associated with inflammatory bowel diseaseThe immunogenetics of primary biliary cirrhosis: A comprehensive reviewThe aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune responseAryl hydrocarbon receptor control of adaptive immunityFrom IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokinesToward understanding the role of aryl hydrocarbon receptor in the immune system: current progress and future trendsMechanisms underlying helper T-cell plasticity: implications for immune-mediated disease.The Ikaros family of zinc-finger proteinsThe myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteinsLenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cellsGenetic and epigenetic fine mapping of causal autoimmune disease variantsMicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitisSolving the genetic puzzle of systemic lupus erythematosus.miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammationModeling genome-wide dynamic regulatory network in mouse lungs with influenza infection using high-dimensional ordinary differential equations.Human IL-6RhiTIGIT- CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile.Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells.Ubiquitous points of control over regulatory T cells.IL-21 induces IL-22 production in CD4+ T cells.Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor IkarosIn silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo.The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells.Transcriptional and epigenetic regulation of T-helper lineage specification.Role and therapeutic value of dendritic cells in central nervous system autoimmunity.Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation.SIRT1 deacetylates RORγt and enhances Th17 cell generationIFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling.CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.Differential regulation of Th17 and T regulatory cell differentiation by aryl hydrocarbon receptor dependent xenobiotic response element dependent and independent pathwaysMetabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T CellsCD101 inhibits the expansion of colitogenic T cells.Transcriptional regulatory networks for CD4 T cell differentiation.Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21E3 ubiquitin ligases SIAH1/2 regulate hypoxia-inducible factor-1 (HIF-1)-mediated Th17 cell differentiation.Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity.Aryl hydrocarbon receptor: Linking environment to immunity.Helios Controls a Limited Subset of Regulatory T Cell Functions
P2860
Q24626339-395438AB-5C86-4408-B778-E41B428B1626Q26775934-23FC4977-07E2-45F5-B85A-F5445711330DQ26801377-928A3A6C-2AFB-4348-B36E-130D5668D4E2Q26991621-2E39D849-1D67-476C-8D67-173C9FC79C38Q26991793-C4BF9DA0-2AEC-44D8-9F31-174D5798A4E4Q27008912-4A5BE44B-A5BF-4EB1-91A2-88FB29D2B9C9Q27026898-2B0BD8B4-24BC-45F3-9113-35403D4BB405Q27687830-BABDD012-2D47-407A-B6D8-E2E91AA57B3CQ28066194-4C2B94D1-C5D2-44C2-9099-203472987965Q28303081-A99A930F-9661-4A49-B7C2-D5AC7201FB89Q28303091-EDE66684-073E-415C-9D3C-EA155F44CC95Q28649603-96A6EBC6-0D24-48E1-869A-4987535513E4Q28975627-AB6971EA-8C01-44FD-823E-A1D7D1ACE3B7Q33359121-41358E4E-2C85-4504-A28F-58BC8777F848Q33556109-4EC55AEB-9120-4936-977B-1BA35F62421FQ33572880-222FC415-6B69-42DE-BC8F-CA0152E45ADFQ33800947-0CB8320F-1C83-417D-B6F3-856DC38BF7DAQ33806421-9C7B104D-2CEC-4978-97B0-A8CA0824229AQ33850593-013204F5-A9E0-4BA3-94FA-A5A6CCAAB902Q34148906-76047878-F32C-4762-ACC8-08D69398DC0CQ34289345-FECB26E8-AD51-4A2A-8F5B-E6E0BAE06562Q34360082-E89C0532-D5DD-4054-9BF4-152676ACBA4DQ34618230-3463C0D4-0181-4927-827D-8E7B602F17BFQ34631682-2CC5F268-B847-4CEA-99C1-E8DAD74A33F7Q34924088-4B4C0BE2-EDCA-4FC8-BB74-617F278996F0Q35064910-3AC48E66-1894-4DEA-8993-7721EA487C5EQ35554348-5DC9D097-A2F2-4172-9F71-7EDC6AE1B171Q35568434-694D942A-95A1-4C9B-BE99-5AA0283331E2Q35613108-895B317F-561F-40BC-AD42-2D5B8ABA4444Q35640007-7AA79877-E709-45F1-86C0-F08CD0CEDCF4Q35753510-E42DC1A4-382F-4CBB-B61F-D43CE5C0D054Q35765467-9095F7A3-B3A7-4210-AEE5-930BC071E1F4Q35816008-90EA55F0-483E-4DD5-B829-5AD2A00AC633Q35905213-2AE62B94-488D-4409-B4D5-236D1E17A406Q36015482-B5244035-A113-48BE-8580-FA0C460CC2ADQ36189902-92E56CBB-CBB4-4CE6-B3C9-18FBF088B04BQ36321913-F07A0B7E-701E-4BD2-B5F6-D29D1AA10216Q36352374-62ACAA51-0B46-4464-9C05-3834EF76BA6FQ36378234-22E37DB3-E45E-41E8-9BAF-D17399B52DCBQ36387212-9F9BF187-B9B1-4CF0-A3FA-0E74EE684905
P2860
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
@ast
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
@en
type
label
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
@ast
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
@en
prefLabel
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
@ast
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
@en
P2093
P2860
P356
P1433
P1476
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
@en
P2093
Deepak Kumar
Evan J Burns
Francisco J Quintana
John Seavitt
Katia Georgopoulos
Manu Rangachari
Meghan Nadeau
P2860
P304
P356
10.1038/NI.2363
P407
P577
2012-07-01T00:00:00Z