Promoter cross-talk via a shared enhancer explains paternally biased expression of Nctc1 at the Igf2/H19/Nctc1 imprinted locus. - sprookjes - yvandenbroek - TriplyDB

Promoter cross-talk via a shared enhancer explains paternally biased expression of Nctc1 at the Igf2/H19/Nctc1 imprinted locus.

Promoter cross-talk via a shared enhancer explains paternally biased expression of Nctc1 at the Igf2/H19/Nctc1 imprinted locus.

http://www.wikidata.org/entity/Q36559183

about

The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regeneration.Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors.Human endogenous retroviruses sustain complex and cooperative regulation of gene-containing loci and unannotated megabase-sized regions.Methylome-wide Sequencing Detects DNA Hypermethylation Distinguishing Indolent from Aggressive Prostate Cancer H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase.Characterizing a distal muscle enhancer in the mouse Igf2 locus.The Igf2/H19 muscle enhancer is an active transcriptional complex.Long noncoding RNAs, emerging players in muscle differentiation and disease.H19ICR mediated transcriptional silencing does not require target promoter methylation.Loss of imprinting mutations define both distinct and overlapping roles for misexpression of IGF2 and of H19 lncRNA.The complex genetics of human insulin-like growth factor 2 are not reflected in public databases.Onco-Multi-OMICS Approach: A New Frontier in Cancer Research

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P2860

Promoter cross-talk via a shared enhancer explains paternally biased expression of Nctc1 at the Igf2/H19/Nctc1 imprinted locus.

http://www.wikidata.org/entity/Q36559183

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2012 nî lūn-bûn

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Promoter cross-talk via a shar ...... gf2/H19/Nctc1 imprinted locus.

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Promoter cross-talk via a shar ...... gf2/H19/Nctc1 imprinted locus.

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Promoter cross-talk via a shar ...... Igf2/H19/Nctc1 imprinted locus

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Bokkee Eun

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Claudia M Gebert

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Megan L Sampley

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P2860

A large fraction of extragenic RNA pol II transcription sites overlap enhancers

CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

Capturing chromosome conformation

Ectopic expression of the H19 gene in mice causes prenatal lethality

Disruption of imprinting caused by deletion of the H19 gene region in mice

An enhancer deletion affects both H19 and Igf2 expression

Landscape of transcription in human cells

Widespread transcription at neuronal activity-regulated enhancers

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10.1093/NAR/GKS1182

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