The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the beta-type receptor for the platelet-derived growth factor but not other related tyrosine kinase-containing receptors to induce cellular transformation.
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Packing contacts can mediate highly specific interactions between artificial transmembrane proteins and the PDGFbeta receptor.Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor.Bovine papillomavirus E5 protein induces oligomerization and trans-phosphorylation of the platelet-derived growth factor beta receptor.The bovine papillomavirus E5 protein requires a juxtamembrane negative charge for activation of the platelet-derived growth factor beta receptor and transformation of C127 cells.Endoplasmic reticulum-localized human papillomavirus type 16 E5 protein alters endosomal pH but not trans-Golgi pH.The E5 proteinsMultiple transmembrane amino acid requirements suggest a highly specific interaction between the bovine papillomavirus E5 oncoprotein and the platelet-derived growth factor beta receptor.Viral miniproteinsPapillomavirus E5: the smallest oncoprotein with many functions.The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues.Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous beta receptor for platelet-derived growth factor in mouse C127 cells.Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein.E5 oncoprotein transmembrane mutants dissociate fibroblast transforming activity from 16-kilodalton protein binding and platelet-derived growth factor receptor binding and phosphorylation.Identification of amino acids in the transmembrane and juxtamembrane domains of the platelet-derived growth factor receptor required for productive interaction with the bovine papillomavirus E5 protein.Hydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF Receptor.Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling.The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and phosphatidylinositol-3'-kinase in NIH 3T3 cells.The bovine papillomavirus E5 protein and the PDGF beta receptor: it takes two to tango.E5 oncoprotein retained in the endoplasmic reticulum/cis Golgi still induces PDGF receptor autophosphorylation but does not transform cellsCompensatory mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor β receptor reveal a complex direct transmembrane interaction.Role of glutamine 17 of the bovine papillomavirus E5 protein in platelet-derived growth factor beta receptor activation and cell transformation.Human papillomavirus type 16 E5 protein affects cell-cell communication in an epithelial cell lineProductive interaction between transmembrane mutants of the bovine papillomavirus E5 protein and the platelet-derived growth factor beta receptor.Upregulation of swelling-activated Cl- channel sensitivity to cell volume by activation of EGF receptors in murine mammary cells.Golgi alkalinization by the papillomavirus E5 oncoprotein.Analysis of activated platelet-derived growth factor β receptor and Ras-MAP kinase pathway in equine sarcoid fibroblasts.In vitro dimerization of the bovine papillomavirus E5 protein transmembrane domain.Two transmembrane dimers of the bovine papillomavirus E5 oncoprotein clamp the PDGF β receptor in an active dimeric conformation.
P2860
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P2860
The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the beta-type receptor for the platelet-derived growth factor but not other related tyrosine kinase-containing receptors to induce cellular transformation.
description
1994 nî lūn-bûn
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1994年の論文
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1994年論文
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1994年論文
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1994年論文
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name
The bovine papillomavirus type ...... nduce cellular transformation.
@ast
The bovine papillomavirus type ...... nduce cellular transformation.
@en
type
label
The bovine papillomavirus type ...... nduce cellular transformation.
@ast
The bovine papillomavirus type ...... nduce cellular transformation.
@en
prefLabel
The bovine papillomavirus type ...... nduce cellular transformation.
@ast
The bovine papillomavirus type ...... nduce cellular transformation.
@en
P2093
P2860
P1433
P1476
The bovine papillomavirus type ...... nduce cellular transformation.
@en
P2093
D J Goldstein
J H Pierce
M A Heidaran
R Schlegel
S Aaronson
P2860
P304
P407
P577
1994-07-01T00:00:00Z